Examination of the MSX1 gene in patients with Parkinson’s disease

Authors: Deng, H.; Zhu, S. H.; Le, W. D.1; Yang, H. R.; Lv, H. W.2; Xu, H. B.2; Xie, W. J.1; Jankovic, J.1

Source: Acta Neurologica Scandinavica, Volume 120, Number 6, December 2009 , pp. 442-444(3)

Publisher: Wiley-Blackwell

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Abstract:

Deng H, Zhu SH, Le WD, Yang HR, Lv HW, Xu HB, Xie WJ, Jankovic J. Examination of the MSX1 gene in patients with Parkinson’s disease. Acta Neurol Scand 2009: 120: 442–444.

© 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard. Background – 

Several genetic variants in transcription factor genes have been reported to be associated with Parkinson’s disease (PD). The muscle segment homeobox drosophila homolog of 1 gene (MSX1) is a major upstream regulator of the dopaminergic neuronal subtype specification. Aims of the study – 

To determine whether genetic variation in the coding region of the MSX1 gene plays a role in the etiology of PD. Methods – 

We searched for genetic variations in the coding region of the MSX1 gene in 202 patients with PD and 200 normal controls by PCR-single-strand conformation polymorphism (PCR-SSCP) and sequencing. Results – 

No mutation in the MSX1 gene was identified in our cohort. Conclusions – 

Mutations in the coding region of the MSX1 gene play little or no role in the development of PD.

Keywords: Parkinson’s disease; coding region; muscle segment homeobox drosophila homolog of 1 gene; mutation; transcription factor

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0404.2009.01271.x

Affiliations: 1: Department of Neurology, Baylor College of Medicine, Houston, TX, USA 2: Center for Experimental Medicine, the Third Xiangya Hospital, Central South University, China

Publication date: December 1, 2009

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