Examination of the MSX1 gene in patients with Parkinson’s disease
Abstract:Deng H, Zhu SH, Le WD, Yang HR, Lv HW, Xu HB, Xie WJ, Jankovic J. Examination of the MSX1 gene in patients with Parkinson’s disease. Acta Neurol Scand 2009: 120: 442–444.
© 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard. Background –
Several genetic variants in transcription factor genes have been reported to be associated with Parkinson’s disease (PD). The muscle segment homeobox drosophila homolog of 1 gene (MSX1) is a major upstream regulator of the dopaminergic neuronal subtype specification. Aims of the study –
To determine whether genetic variation in the coding region of the MSX1 gene plays a role in the etiology of PD. Methods –
We searched for genetic variations in the coding region of the MSX1 gene in 202 patients with PD and 200 normal controls by PCR-single-strand conformation polymorphism (PCR-SSCP) and sequencing. Results –
No mutation in the MSX1 gene was identified in our cohort. Conclusions –
Mutations in the coding region of the MSX1 gene play little or no role in the development of PD.
Document Type: Research Article
Publication date: 2009-12-01