ApolipoproteinE epsilon 4 allele is not associated with disease course and severity in multiple sclerosis
Abstract:Portaccio E, Zipoli V, Goretti B, Hakiki B, Nacmias B, Siracusa G, Sorbi S, Amato MP. ApolipoproteinE epsilon 4 allele is not associated with disease course and severity in multiple sclerosis.
Acta Neurol Scand 2009: 120: 439–441.
© 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard. Background –
No study has assessed the association between apolipoproteinE (APOE) and multiple sclerosis (MS) forms grouped by also taking into account cognitive performance. Aims of the study –
To assess the relationship between APOE and disease course, particularly focusing on benign MS (BMS), defined as also including cognitive preservation. Methods –
In 173 consecutive patients, we assessed the association between APOE and MS course and severity. Results –
Twenty-nine APOE-4 carriers were identified. The 4 allele was not associated with BMS. Moreover, it was associated neither with other disease courses nor with the time to reach disability milestones and secondary progression. Conclusion –
Although plausible, the association between APOE and MS course (particularly with BMS defined by including cognitive preservation) and disease severity remains controversial.
Document Type: Research Article
Publication date: December 1, 2009