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ApolipoproteinE epsilon 4 allele is not associated with disease course and severity in multiple sclerosis

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Abstract:

Portaccio E, Zipoli V, Goretti B, Hakiki B, Nacmias B, Siracusa G, Sorbi S, Amato MP. ApolipoproteinE epsilon 4 allele is not associated with disease course and severity in multiple sclerosis.

Acta Neurol Scand 2009: 120: 439–441.

© 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard. Background – 

No study has assessed the association between apolipoproteinE (APOE) and multiple sclerosis (MS) forms grouped by also taking into account cognitive performance. Aims of the study – 

To assess the relationship between APOE and disease course, particularly focusing on benign MS (BMS), defined as also including cognitive preservation. Methods – 

In 173 consecutive patients, we assessed the association between APOE and MS course and severity. Results – 

Twenty-nine APOE-4 carriers were identified. The 4 allele was not associated with BMS. Moreover, it was associated neither with other disease courses nor with the time to reach disability milestones and secondary progression. Conclusion – 

Although plausible, the association between APOE and MS course (particularly with BMS defined by including cognitive preservation) and disease severity remains controversial.

Keywords: apolipoprotein E; benign; disability; multiple sclerosis

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0404.2009.01278.x

Publication date: December 1, 2009

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