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The combinations of TNFα–308 and IL-6 –174 or IL-10 –1082 genes polymorphisms suggest an association with susceptibility to sporadic late-onset Alzheimer’s disease

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Vural P, Değirmencioğlu S, Parıldar-Karpuzoğlu H, Doğru-Abbasoğlu S, Hanagasi HA, Karadağ B, Gürvit H, Emre M, Uysal M. The combinations of TNFα–308 and IL-6–174 or IL-10 –1082 genes polymorphisms suggest an association with susceptibility to sporadic late-onset Alzheimer’s disease.

Acta Neurol Scand 2009: 120: 396–401.

© 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard. Objective – 

Single nucleotide polymorphisms in the regulatory regions of the cytokine genes for tumor necrosis factor α (TNFα), interleukin (IL)-6 and IL-10 have been suggested to influence the risk of Alzheimer’s disease (AD) with conflicting results. Aim – 

To investigate the TNFα–308, IL-6 –174 and IL-10 –1082 gene polymorphisms as susceptibility factors for AD. Methods – 

We analyzed genotype and allele distributions of these polymorphisms in 101 sporadic AD patients and 138 healthy controls. Results – 

Heterozygotes (AG) or combined genotype (AG+AA) for IL-10 –1082 were associated with approximately two-fold increase in the risk of AD. Carriers of A alleles of both TNFα–308 and IL-10 –1082 had 6.5 times higher risk for AD in comparison with non-carriers. Concomitant presence of both mutant TNFα–308 A and IL-6 –174 C alleles raised three-fold the AD risk, whereas there was no notable risk for AD afflicted by IL-6 –174 polymorphism alone. Conclusion – 

Our results suggest that TNFα and IL-10 promoter polymorphism might be a risk factor for AD. The combined effects of TNFα–308, IL-6 –174 and IL-10 –1082 variant alleles may be more decisive to induce functional differences and modify the risk for AD.
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Keywords: Alzheimer’s disease; IL-10; IL-6; TNFα; cytokine; polymorphism

Document Type: Research Article

Affiliations: 1: Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Çapa, Istanbul, Turkey 2: Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Çapa, Istanbul, Turkey 3: Department of Internal Medicine, Division of Geriatrics, Cerrahpaşa School of Medicine, Istanbul University, Istanbul, Turkey

Publication date: 2009-12-01

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