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The effects of chronic administration of sumatriptan and dipyrone on serotonergic system in the rat brain: an immunohistochemical study

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Abstract:

Genç E, Avunduk MC, Oğuz Genç B, Saide Şahin A, Öz M. The effects of chronic administration of sumatriptan and dipyrone on serotonergic system in the rat brain: an immunohistochemical study.

Acta Neurol Scand: 2009: 120: 264–269.

© 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard. Objective – 

To investigate the effects of chronic high dose sumatriptan and dipyrone treatment on central serotonergic system in rats. Materials and methods – 

Male Sprague–Dawley rats (seven per group) were daily injected with sumatriptan (3 mg/kg), dipyrone (400 mg/kg) or saline for 30 days. The brains of animals were surgically removed and immunohistochemically stained for serotonin. Serotonin-positive stained cells were counted automatically by using a computerized image analysis program. Statistical analysis carried out using one-way ANOVA followed by post hoc Tukey test. Results – 

A significant decrease in serotonin-positive cells in the brainstem was observed after chronic sumatriptan administration while chronic use of dipyrone induced a significant increase in serotonin-positive cells both in the cortex and midbrain. Conclusion – 

Our data suggest that central serotonergic system might be modified by chronic use of sumatriptan and dipyrone.

Keywords: dipyrone; immunohistochemical staining; rat; serotonin expression; sumatriptan

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0404.2008.01153.x

Affiliations: 1: Departments of Neurology 2: Pathology 3: Pharmacology, Meram School of Medicine, Selcuk University, Konya, Turkey 4: Experimental Medicine and Research Center, Meram School of Medicine, Selcuk University, Konya, Turkey

Publication date: October 1, 2009

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