The effects of chronic administration of sumatriptan and dipyrone on serotonergic system in the rat brain: an immunohistochemical study
Acta Neurol Scand: 2009: 120: 264–269.
© 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard. Objective –
To investigate the effects of chronic high dose sumatriptan and dipyrone treatment on central serotonergic system in rats. Materials and methods –
Male Sprague–Dawley rats (seven per group) were daily injected with sumatriptan (3 mg/kg), dipyrone (400 mg/kg) or saline for 30 days. The brains of animals were surgically removed and immunohistochemically stained for serotonin. Serotonin-positive stained cells were counted automatically by using a computerized image analysis program. Statistical analysis carried out using one-way ANOVA followed by post hoc Tukey test. Results –
A significant decrease in serotonin-positive cells in the brainstem was observed after chronic sumatriptan administration while chronic use of dipyrone induced a significant increase in serotonin-positive cells both in the cortex and midbrain. Conclusion –
Our data suggest that central serotonergic system might be modified by chronic use of sumatriptan and dipyrone.
Document Type: Research Article
Affiliations: 1: Departments of Neurology 2: Pathology 3: Pharmacology, Meram School of Medicine, Selcuk University, Konya, Turkey 4: Experimental Medicine and Research Center, Meram School of Medicine, Selcuk University, Konya, Turkey
Publication date: 01 October 2009