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CD46 expression and HHV-6 infection in patients with multiple sclerosis

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Alvarez-Lafuente R, Garcia-Montojo M, De Las Heras V, Dominguez-Mozo MI, Bartolome M, Arroyo R. CD46 expression and HHV-6 infection in patients with multiple sclerosis.

Acta Neurol Scand: 2009: 120: 246–250.

© 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard. Objectives – 

The aim of this study was to investigate the possible association between the levels of the CD46 expression, and the presence and viral load of HHV-6 in patients with multiple sclerosis (MS). Methods – 

We collected blood and serum samples of 103 patients with MS and the same number of healthy blood donors (HBD); total DNA and RNA was extracted from peripheral blood mononuclear cells (PBMCs) and serum, and then analyzed using quantitative real-time PCR for the detection of CD46 transcripts and HHV-6 genomes; the expression of rRNA18s was used for the calculation of the relative expression of CD46. Results – 

Almost 80% of patients with MS had increased levels of CD46 in comparison with HBD, and a positive correlation was also found between the over-expression of CD46 in patients with MS and the HHV-6 DNA prevalence and viral load in the blood and serum. Discussion – 

Therefore, the up-regulation of CD46 expression in patients with MS with HHV-6 infection could constitute an immunopathogenic factor that should be further investigated to elucidate its role in MS.

Keywords: CD46; HHV-6; multiple sclerosis; quantitative PCR

Document Type: Research Article


Publication date: October 1, 2009


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