MR peri-CSF lesions and CSF oligoclonal bands in Italian multiple sclerosis patients
Abstract:Pichiecchio A, Tavazzi E, Maccabelli G, Ponzio M, Romani A, Schiappacassa R, Poloni GU, Franciotta D, Roccatagliata L, Bergamaschi R, Bastianello S. MR peri-CSF lesions and CSF oligoclonal bands in Italian multiple sclerosis patients.
Acta Neurol Scand: 2009: 120: 242–245.
© 2008 The Authors Journal compilation © 2008 Blackwell Munksgaard. Objectives –
We investigated the association between brain lesion distribution and the presence of oligoclonal IgG bands (OCBs) in Italian multiple sclerosis (MS) patients. Materials and methods –
We retrospectively selected brain magnetic resonance imaging (MRI) uniformly performed in 56 relapsing patients (41 patients OCB positive). Results –
Brain lesions in periventricular areas occurred in 92.86% of the patients (100% OCB+ and 73.33% OCB−) (P = 0.004), but we did not find a significant difference for their median volume (P = 0.553) and median number (P = 0.606) between the two groups. Parenchymal lesions occurred in 76.8% of the patients with a similar distribution (P = 1.00) and no significant difference in the median volume (P = 0.818) and number (P = 0.643) between the two groups. Conclusions –
The present study on cohort of Italian MS patients demonstrated a lack of correlation between lesion distribution and OCBs, suggesting that B cells producing them could be localized both in meningeal niches and cerebral parenchyma.
Document Type: Research Article
Affiliations: 1: Neuroradiology Unit, Neurological Institute I.R.C.C.S. “Fondazione C.Mondino”, University of Pavia, Pavia, Italy 2: Multiple Sclerosis Centre, Neurological Institute I.R.C.C.S. “Fondazione C.Mondino”, Pavia, Italy 3: Department of Health Sciences, Unit of Medical Statistics and Epidemiology, University of Pavia, Pavia, Italy 4: Laboratory of Neuroimmunology, Neurological Institute I.R.C.C.S. “Fondazione C.Mondino”, University of Pavia, Pavia, Italy 5: Department of Neuroscience, Ophthalmology and Genetics, Genoa, Italy
Publication date: October 1, 2009