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MR peri-CSF lesions and CSF oligoclonal bands in Italian multiple sclerosis patients

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Pichiecchio A, Tavazzi E, Maccabelli G, Ponzio M, Romani A, Schiappacassa R, Poloni GU, Franciotta D, Roccatagliata L, Bergamaschi R, Bastianello S. MR peri-CSF lesions and CSF oligoclonal bands in Italian multiple sclerosis patients.

Acta Neurol Scand: 2009: 120: 242–245.

© 2008 The Authors Journal compilation © 2008 Blackwell Munksgaard. Objectives – 

We investigated the association between brain lesion distribution and the presence of oligoclonal IgG bands (OCBs) in Italian multiple sclerosis (MS) patients. Materials and methods – 

We retrospectively selected brain magnetic resonance imaging (MRI) uniformly performed in 56 relapsing patients (41 patients OCB positive). Results – 

Brain lesions in periventricular areas occurred in 92.86% of the patients (100% OCB+ and 73.33% OCB−) (P = 0.004), but we did not find a significant difference for their median volume (P = 0.553) and median number (P = 0.606) between the two groups. Parenchymal lesions occurred in 76.8% of the patients with a similar distribution (P = 1.00) and no significant difference in the median volume (P = 0.818) and number (P = 0.643) between the two groups. Conclusions – 

The present study on cohort of Italian MS patients demonstrated a lack of correlation between lesion distribution and OCBs, suggesting that B cells producing them could be localized both in meningeal niches and cerebral parenchyma.
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Keywords: immunoglobulin G; magnetic resonance imaging; multiple sclerosis; oligoclonal bands

Document Type: Research Article

Affiliations: 1: Neuroradiology Unit, Neurological Institute I.R.C.C.S. “Fondazione C.Mondino”, University of Pavia, Pavia, Italy 2: Multiple Sclerosis Centre, Neurological Institute I.R.C.C.S. “Fondazione C.Mondino”, Pavia, Italy 3: Department of Health Sciences, Unit of Medical Statistics and Epidemiology, University of Pavia, Pavia, Italy 4: Laboratory of Neuroimmunology, Neurological Institute I.R.C.C.S. “Fondazione C.Mondino”, University of Pavia, Pavia, Italy 5: Department of Neuroscience, Ophthalmology and Genetics, Genoa, Italy

Publication date: 2009-10-01

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