Skip to main content

MR peri-CSF lesions and CSF oligoclonal bands in Italian multiple sclerosis patients

Buy Article:

$51.00 plus tax (Refund Policy)

Abstract:

Pichiecchio A, Tavazzi E, Maccabelli G, Ponzio M, Romani A, Schiappacassa R, Poloni GU, Franciotta D, Roccatagliata L, Bergamaschi R, Bastianello S. MR peri-CSF lesions and CSF oligoclonal bands in Italian multiple sclerosis patients.

Acta Neurol Scand: 2009: 120: 242–245.

© 2008 The Authors Journal compilation © 2008 Blackwell Munksgaard. Objectives – 

We investigated the association between brain lesion distribution and the presence of oligoclonal IgG bands (OCBs) in Italian multiple sclerosis (MS) patients. Materials and methods – 

We retrospectively selected brain magnetic resonance imaging (MRI) uniformly performed in 56 relapsing patients (41 patients OCB positive). Results – 

Brain lesions in periventricular areas occurred in 92.86% of the patients (100% OCB+ and 73.33% OCB−) (P = 0.004), but we did not find a significant difference for their median volume (P = 0.553) and median number (P = 0.606) between the two groups. Parenchymal lesions occurred in 76.8% of the patients with a similar distribution (P = 1.00) and no significant difference in the median volume (P = 0.818) and number (P = 0.643) between the two groups. Conclusions – 

The present study on cohort of Italian MS patients demonstrated a lack of correlation between lesion distribution and OCBs, suggesting that B cells producing them could be localized both in meningeal niches and cerebral parenchyma.

Keywords: immunoglobulin G; magnetic resonance imaging; multiple sclerosis; oligoclonal bands

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0404.2008.01147.x

Affiliations: 1: Neuroradiology Unit, Neurological Institute I.R.C.C.S. “Fondazione C.Mondino”, University of Pavia, Pavia, Italy 2: Multiple Sclerosis Centre, Neurological Institute I.R.C.C.S. “Fondazione C.Mondino”, Pavia, Italy 3: Department of Health Sciences, Unit of Medical Statistics and Epidemiology, University of Pavia, Pavia, Italy 4: Laboratory of Neuroimmunology, Neurological Institute I.R.C.C.S. “Fondazione C.Mondino”, University of Pavia, Pavia, Italy 5: Department of Neuroscience, Ophthalmology and Genetics, Genoa, Italy

Publication date: October 1, 2009

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more