Morphological and immunohistochemical characterization of paraneoplastic cerebellar degeneration associated with Yo antibodies
Abstract:Storstein A, Krossnes BK, Vedeler CA. Morphological and immunohistochemical characterization of paraneoplastic cerebellar degeneration associated with Yo antibodies.
Acta Neurol Scand 2009: 120: 64–67.
© 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard. Introduction –
Immunohistochemical studies of paraneoplastic cerebellar degeneration (PCD) are rare, and the findings vary. Materials and methods –
We performed morphological and immunohistochemical characterization of the brain, medulla and tumour of two patients with PCD, Yo antibodies and ovarian adenocarcinoma. Results –
The cerebellum of both patients had extensive loss of Purkinje cells. Microglia activation and T cells were found in the cerebellum, but B cells or deposits of IgG or complement were not detected. Microglia activation was also present in the brain stem and medulla. T cells were found in the ovarian adenocarcinoma. Conclusion –
PCD is characterized by loss of Purkinje cells and microglia activation, and the presence of T cells indicates cellular immune reactions in PCD and in ovarian cancer.