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Morphological and immunohistochemical characterization of paraneoplastic cerebellar degeneration associated with Yo antibodies

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Abstract:

Storstein A, Krossnes BK, Vedeler CA. Morphological and immunohistochemical characterization of paraneoplastic cerebellar degeneration associated with Yo antibodies.

Acta Neurol Scand 2009: 120: 64–67.

© 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard. Introduction – 

Immunohistochemical studies of paraneoplastic cerebellar degeneration (PCD) are rare, and the findings vary. Materials and methods – 

We performed morphological and immunohistochemical characterization of the brain, medulla and tumour of two patients with PCD, Yo antibodies and ovarian adenocarcinoma. Results – 

The cerebellum of both patients had extensive loss of Purkinje cells. Microglia activation and T cells were found in the cerebellum, but B cells or deposits of IgG or complement were not detected. Microglia activation was also present in the brain stem and medulla. T cells were found in the ovarian adenocarcinoma. Conclusion – 

PCD is characterized by loss of Purkinje cells and microglia activation, and the presence of T cells indicates cellular immune reactions in PCD and in ovarian cancer.

Keywords: Yo antibody; autopsy; paraneoplastic cerebellar degeneration

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0404.2008.01138.x

Affiliations: Department of Pathology, Haukeland University Hospital, Bergen, Norway

Publication date: July 1, 2009

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