Skip to main content

Neurological comorbidity and epilepsy: implications for treatment

Buy Article:

$51.00 plus tax (Refund Policy)

Abstract:

Zaccara G. Neurological comorbidity and epilepsy: implications for treatment.

Acta Neurol Scand 2009: 120: 1–15.

© 2009 The Author Journal compilation © 2009 Blackwell Munksgaard.

Epilepsy is a chronic condition that may be associated with several other diseases. In these cases, we should consider the following points: (1) antiepileptic drug (AED) treatment may positively or negatively affect comorbid disease, (2) drugs used for treatment of co-morbid disease may influence seizure threshold, (3) AED toxicity can be affected by a comorbid condition and (4) co-administration of AEDs with drugs used for treatment of comorbid conditions can be associated with clinically relevant drug–drug interactions. In this article, we discuss problems that are usually encountered when an appropriate AED treatment has to be selected in newly diagnosed epileptic patients who also have (an)other neurological disease(s). Comorbidity of epilepsy with cerebrovascular diseases, dementias, mental retardation, attention deficit and hyperactivity disorder, brain tumours, infections of the CNS, migraine, sleep disturbances (obstructive sleep apnoea syndrome), substance abuse and multiple sclerosis is discussed.

Keywords: antiepileptic drugs; co-morbidity; drug interactions; epilepsy

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0404.2008.01146.x

Publication date: July 1, 2009

mksg/ane/2009/00000120/00000001/art00001
dcterms_title,dcterms_description,pub_keyword
6
5
20
40
5

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more