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Striatal [123I] FP-CIT SPECT demonstrates dopaminergic deficit in a sporadic case of Creutzfeldt–Jakob disease

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Ragno M, Scarcella MG, Cacchiò G, Capellari S, Di Marzio F, Parchi P, Trojano L. Striatal [123I] FP-CIT SPECT demonstrates dopaminergic deficit in a sporadic case of Creutzfeldt–Jakob disease.

Acta Neurol Scand 2009: 119: 131–134.

© 2008 The Authors Journal compilation © 2008 Blackwell Munksgaard. Background – 

The frequent occurrence of movement disorders such as myoclonus, parkinsonism and dystonia, strongly suggests an involvement of the dopaminergic system in sporadic Creutzfeldt-Jakob disease (sCJD), but this issue has not been specifically addressed yet. Methods – 

We report a patient who after a sub-acute focal clinical onset, developed the full clinical picture of probable sCJD. Given the early unilateral right extrapyramidal rigidity, the patient was assessed by single-photon emission computed tomography of the dopamine transporter (DAT) using [123I] FP-CIT. Results – 

DAT-scan demonstrated reduced values of presynaptic receptorial trace in the putamen, particularly on the left side, consistent with functional putaminal dopaminergic presynaptic alteration. Conclusions – 

The present observation emphasizes the possible role of DAT imaging studies in the investigation of the pathogenesis of movement disorders in CJD.

Keywords: Creutzfeldt–Jakob syndrome; dopaminergic activity; unilateral Parkinsonism

Document Type: Research Article


Affiliations: 1: Division of Neurology, ‘C & G Mazzoni’ Hospital, Ascoli Piceno, Italy 2: Department of Neurological Sciences, University of Bologna, Italy 3: Department of Psychology, Second University of Naples, Italy

Publication date: 2009-02-01

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