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High insulin levels are positively associated with peripheral nervous system function

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Isojärvi H, Kallio M, Korpelainen R, Kaikkonen K, Jämsä T, Keinänen-Kiukaanniemi S. High insulin levels are positively associated with peripheral nervous system function.

Acta Neurol Scand 2009: 119: 107–112.

© 2008 The Authors Journal compilation © 2008 Blackwell Munksgaard. Objective – 

The aim of this study was to analyze peripheral nervous system (PNS) function in overweight and obese individuals. Materials and Methods – 

Forty-four adult non-diabetic overweight individuals were recruited. Peroneal motor nerve conduction and radial, sural, and medial plantar sensory nerve conduction were studied. Insulin and glucose levels were determined twice (over a 2- to 3-year period) with an oral glucose tolerance test (OGTT). Multiple stepwise linear regression models adjusted for age, height, weight, and skin temperature were used to analyze the data. Results – 

Analysis revealed that baseline insulin levels measured 120 min after an OGTT explained 18% of the variation in peroneal F-wave minimum latency, 8% of peroneal F-wave maximum latency variation, 15% of sural sensory latency variation, 13% of sural sensory nerve conduction velocity (NCV) variation, and 10% of the variation in medial plantar sensory NCV. Discussion and Conclusion – 

Our study shows that serum insulin levels measured 120 min after an OGGT are positively associated with PNS function. High insulin levels without notably high glucose levels appear to be beneficial for the function of the PNS.

Keywords: high insulin levels; nerve conduction studies; obesity; peripheral nervous system function

Document Type: Research Article


Affiliations: 1: Department of Medical Technology, Institute of Biomedicine, University of Oulu, Oulu, Finland 2: Department of Clinical Neurophysiology, Oulu University Hospital, Oulu, Finland 3: Department of Sports Medicine, Deaconess Institute of Oulu, Oulu, Finland 4: Institute of Health Science, Unit of General Practice, Oulu University Hospital, Oulu, Finland

Publication date: 2009-02-01

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