Impact of early surgery after aneurysmal subarachnoid haemorrhage

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Abstract:

van der Jagt M, Hasan D, Dippel DWJ, van Dijk EJ, Avezaat CJJ, Koudstaal PJ. Impact of early surgery after aneurysmal subarachnoid haemorrhage.

Acta Neurol Scand 2009: 119: 100–106.

© 2008 The Authors Journal compilation © 2008 Blackwell Munksgaard. Objectives – 

To investigate the effect of early aneurysm surgery (<72 h) on outcome in patients with subarachnoid haemorrhage (SAH). Materials and methods – 

We studied two consecutive series of patients with aneurysmal SAH [postponed surgery (PS) cohort, n = 118, 1989–1992: surgery was planned on day 12 and early surgery (ES) cohort, n = 85, 1996–1998: ES was performed only in patients with Glasgow Coma Scale (GCS) >13]. We used multivariable logistic regression analysis to assess outcome at 3 months. Results – 

Favourable outcome (Glasgow Outcome Scale 4 or 5) was similar in both cohorts. Cerebral ischemia occurred significantly more often in the ES cohort. The occurrence of rebleeds was similar in both cohorts. External cerebrospinal fluid (CSF) drainage was performed more often in the ES cohort (51% vs 19%). Patients with cisternal sum score (CSS) of subarachnoid blood <15 on admission [adjusted odds ratio (OR) for favourable outcome: 6.4, 95% confidence interval (CI) 1.0–39.8] and patients with both CSS <15 and GCS > 12 on admission benefited from the strategy including ES (OR 10.5, 95% CI 1.1–99.4). Conclusions – 

Our results support the widely adopted practice of ES in good-grade SAH patients.

Keywords: cerebral ischemia; early surgery; outcome; rebleed; subarachnoid haemorrhage

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0404.2008.01064.x

Affiliations: 1: Intensive Care Unit, Schieland Hospital, Schiedam, the Netherlands 2: Department of Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands 3: Department of Neurosurgery, Erasmus MC University Medical Center, Rotterdam, the Netherlands

Publication date: February 1, 2009

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