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Treatment of a patient with myasthenia gravis using antibodies against CD25

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Abstract:

Kakoulidou M, Pirskanen-Matell R, Lefvert AK. Treatment of a patient with myasthenia gravis using antibodies against CD25.

Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2007.00919.x.

© 2007 The Authors Journal compilation © 2007 Blackwell Munksgaard. Objectives – 

To measure clinical and immunological parameters in a patient with myasthenia gravis (MG) treated with antibodies against CD25 (basiliximab, Simulect®). Patient and methods – 

Injections of basiliximab were given repeatedly together with cyclosporin A and corticosteroids for 9 months to a patient with severe MG. Her muscle function score was monitored and the immunological parameters were followed using ELISA, flow cytometry and radioimmunoassay. Results – 

The patient improved moderately and corticosteroid treatment could be withdrawn. The percentage of activated CD4+ T cells decreased during treatment, while that of ‘naïve’ T cells increased. The serum levels of sCD28, sCD152, sCD80, sCD86 and IL-10 decreased. The treatment was stopped due to repeated infections. Conclusion – 

Treatment with basiliximab appears to be suitable only for severely ill patients who do not respond to conventional treatments. However, careful monitoring of side effects is necessary.

Keywords: basiliximab; case study; myasthenia gravis

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0404.2007.00919.x

Affiliations: 1: Immunological Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden 2: Department of Neurology, Karolinska Institutet, Stockholm, Sweden

Publication date: March 1, 2008

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