Skip to main content

Association of estrogen receptor-alpha gene polymorphisms with stroke risk in patients with metabolic syndrome

Buy Article:

$43.00 plus tax (Refund Policy)

Lazaros L, Markoula S, Xita N, Giannopoulos S, Gogou P, Lagos G, Kyritsis AP, Georgiou I. Association of estrogen receptor-alpha gene polymorphisms with stroke risk in patients with metabolic syndrome.

Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2007.00926.x.

© 2007 The Authors Journal compilation © 2007 Blackwell Munksgaard. Objective – 

The vascular protective effects of estrogens are mediated by their binding to the two known estrogen receptors. In this study, we examine the association of stroke with two common polymorphisms of the ESR1 gene in patients with metabolic syndrome. Materials and methods – 

DNA from 130 patients hospitalized for ischemic stroke and 240 healthy controls were genotyped for ESR1 PvuII and XbaI polymorphisms. Results – 

Comparing female and male patients, it was found that CCGG diplotype is more frequent in male patients (P = 0.03). In addition, the AA genotype is associated with the onset of stroke at a younger age in the male patient group (P < 0.05). Conclusions – 

These findings suggest that PvuII and XbaI polymorphisms may affect the age at onset of the first stroke and the probability of developing cerebrovascular disease.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: estrogen receptor-alpha; genetics; metabolic syndrome; stroke

Document Type: Research Article

Affiliations: 1: Laboratory of Medical Genetics, Medical School, University of Ioannina, Ioannina, Greece 2: Department of Neurology, Medical School, University of Ioannina, Ioannina, Greece 3: Department of Endocrinology, Medical School, University of Ioannina, Ioannina, Greece

Publication date: 2008-03-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more