Serum levels and genetic variation of TGF-β1 are not associated with Alzheimer’s disease

$48.00 plus tax (Refund Policy)

Download / Buy Article:

Abstract:

Rodríguez-Rodríguez E, Sánchez-Juan P, Mateo I, Llorca J, Infante J, García-Gorostiaga I, Berciano J, Combarros O. Serum levels and genetic variation of TGF-β1 are not associated with Alzheimer’s disease.

Acta Neurol Scand 2007: 116: 409–412.

© 2007 The Authors Journal compilation © 2007 Blackwell Munksgaard. Objective – 

As transforming growth factor-β1 (TGF-β1) determines important neurotrophic and neuroprotective actions, we postulated serum TGF-β1 levels could be low in Alzheimer’s disease (AD), and TGF-β1 genetic variation could be associated with AD risk through modulating serum TGF-β1 levels. Methods – 

TGF-β1 (−800) (rs 1800468), (−509) (rs 1800469) and (+869) (rs 1982073) polymorphisms were genotyped in 412 AD patients and 406 controls. We measured serum TGF-β1 levels (by ELISA) in 63 AD patients and compared them with 77 age- and gender-matched non-demented controls. Results – 

Serum TGF-β1 levels were not different in AD patients than in controls. Distribution of the allele and genotype frequencies of TGF-β1 polymorphisms did not differ between AD patients and controls. There was no significant correlation between serum TGF-β1 levels and TGF-β1 polymorphisms. Conclusion – 

Serum TGF-β1 concentration is not a potential biomarker for AD, and TGF-β1 genetic variants (−800, −509, and +869) are not risk factors for AD.

Keywords: Alzheimer’s disease; TGF-β1; risk factor; serum

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0404.2007.00892.x

Affiliations: 1: Neurology Service, ‘Marqués de Valdecilla’ University Hospital, University of Cantabria, Santander, Spain 2: Fundación ‘Marqués de Valdecilla’, IFIMAV, Santander, Spain 3: Division of Preventive Medicine, University of Cantabria School of Medicine, Santander, Spain

Publication date: December 1, 2007

Tools

Favourites

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more