Serum levels of glial fibrillary acidic protein correlate to tumour volume of high-grade gliomas

$48.00 plus tax (Refund Policy)

Download / Buy Article:

Abstract:

Brommeland T, Rosengren L, Fridlund S, Hennig R, Isaksen V. Serum levels of glial fibrillary acidic protein correlate to tumour volume of high-grade gliomas.

Acta Neurol Scand 2007: 116: 380–384.

© 2007 The Authors Journal compilation © 2007 Blackwell Munksgaard. Objectives – 

To investigate serum levels of glial fibrillary acidic protein (GFAP) and S-100B in patients with newly diagnosed high-grade gliomas. Materials and methods – 

GFAP and S-100B were measured by enzyme-linked immunosorbent assay techniques in preoperative serum from 31 patients with high-grade gliomas. A database with clinical, radiological and histological variables was created for statistical analyses. Results – 

Mean serum levels of 239 ng/l (range 30–1210 ng/l) for GFAP and 58.3 ng/l (range 22–128 ng/l) for S-100B were found. Of the 31 patients, 16 had elevated levels of GFAP while only two showed increased S-100B concentrations. Tumour size was the only variable significantly associated with serum levels of GFAP (P < 0.0001) with a linear correlation coefficient of 0.67. Conclusions – 

Serum levels of GFAP demonstrated a linear correlation to tumour volume in patients with high-grade gliomas. GFAP seems to be a more reliable biomarker in patients with high-grade gliomas than the commercially available S-100B.

Keywords: GFAP; Ki-67; S-100B; glioma; tumour marker; tumour volume

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0404.2007.00889.x

Affiliations: 1: Neurosurgical Department, University Hospital of North Norway, Tromsø, Norway 2: Institute of Clinical Neuroscience, Department of Neurology, Gothenburg University, Sahlgrenska University Hospital, Gothenburg, Sweden 3: University of Tromsø, Tromsø, Norway 4: Department of Pathology, University Hospital of North Norway, Tromsø, Norway

Publication date: December 1, 2007

Related content

Tools

Favourites

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more