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Serum levels of glial fibrillary acidic protein correlate to tumour volume of high-grade gliomas

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Abstract:

Brommeland T, Rosengren L, Fridlund S, Hennig R, Isaksen V. Serum levels of glial fibrillary acidic protein correlate to tumour volume of high-grade gliomas.

Acta Neurol Scand 2007: 116: 380–384.

© 2007 The Authors Journal compilation © 2007 Blackwell Munksgaard. Objectives – 

To investigate serum levels of glial fibrillary acidic protein (GFAP) and S-100B in patients with newly diagnosed high-grade gliomas. Materials and methods – 

GFAP and S-100B were measured by enzyme-linked immunosorbent assay techniques in preoperative serum from 31 patients with high-grade gliomas. A database with clinical, radiological and histological variables was created for statistical analyses. Results – 

Mean serum levels of 239 ng/l (range 30–1210 ng/l) for GFAP and 58.3 ng/l (range 22–128 ng/l) for S-100B were found. Of the 31 patients, 16 had elevated levels of GFAP while only two showed increased S-100B concentrations. Tumour size was the only variable significantly associated with serum levels of GFAP (P < 0.0001) with a linear correlation coefficient of 0.67. Conclusions – 

Serum levels of GFAP demonstrated a linear correlation to tumour volume in patients with high-grade gliomas. GFAP seems to be a more reliable biomarker in patients with high-grade gliomas than the commercially available S-100B.

Keywords: GFAP; Ki-67; S-100B; glioma; tumour marker; tumour volume

Document Type: Research Article

DOI: https://doi.org/10.1111/j.1600-0404.2007.00889.x

Affiliations: 1: Neurosurgical Department, University Hospital of North Norway, Tromsø, Norway 2: Institute of Clinical Neuroscience, Department of Neurology, Gothenburg University, Sahlgrenska University Hospital, Gothenburg, Sweden 3: University of Tromsø, Tromsø, Norway 4: Department of Pathology, University Hospital of North Norway, Tromsø, Norway

Publication date: 2007-12-01

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