Circulating interleukin-15 and RANTES chemokine in Parkinson’s disease

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Rentzos M, Nikolaou C, Andreadou E, Paraskevas GP, Rombos A, Zoga M, Tsoutsou A, Boufidou F, Kapaki E, Vassilopoulos D. Circulating interleukin-15 and RANTES chemokine in Parkinson’s disease.

Acta Neurol Scand 2007: 116: 374–379.

© 2007 The Authors Journal compilation © 2007 Blackwell Munksgaard.

Interleukin-15 promotes T-cell proliferation, induction of cytolytic effector cells including natural killer (NK) and cytotoxic cells and stimulates B-cell to proliferate and secrete immunoglobulins. RANTES is a C-C beta chemokine with strong chemoattractant activity for T lymphocytes and monocytes. Objectives – 

The objective of our study was to find out whether IL-15 and RANTES are involved in the possible inflammatory reactions of PD. Patients and methods – 

We measured by immunoassay serum IL-15 and RANTES levels in 41 patients with PD in comparison with serum levels in 19 healthy subjects age and sex-matched. IL-15 and RANTES levels were correlated with sex, age, disease duration. H-Y stage and the UPDRS III score in all the studied groups and were also correlated with treatment status in PD patients. Results – 

The PD group presented with significantly increased RANTES levels as compared to the control group (P = 0.0009). No difference was observed as regards IL-15 levels. A strong and significant correlation between RANTES levels and UPDRS III score was observed in PD patients (Rs = 0.42, P = 0.007). Untreated patients had significantly higher RANTES levels as compared to the controls. Conclusions – 

Our findings may suggest a recruitment of activated monocytes, macrophages and T lymphocytes to sites of inflammation in the central nervous system of PD patients.

Keywords: Elisa; IL-15; L-dopa treatment; Parkinson’s disease; RANTES; immunological disturbances; serum

Document Type: Research Article


Affiliations: 1: Departments of Neurology 2: Biopathology-Immunology, School of Medicine, Athens National University, Aeginition Hospital, Athens, Greece

Publication date: December 1, 2007

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