Circulating interleukin-15 and RANTES chemokine in Parkinson’s disease

$48.00 plus tax (Refund Policy)

Download / Buy Article:

Abstract:

Rentzos M, Nikolaou C, Andreadou E, Paraskevas GP, Rombos A, Zoga M, Tsoutsou A, Boufidou F, Kapaki E, Vassilopoulos D. Circulating interleukin-15 and RANTES chemokine in Parkinson’s disease.

Acta Neurol Scand 2007: 116: 374–379.

© 2007 The Authors Journal compilation © 2007 Blackwell Munksgaard.

Interleukin-15 promotes T-cell proliferation, induction of cytolytic effector cells including natural killer (NK) and cytotoxic cells and stimulates B-cell to proliferate and secrete immunoglobulins. RANTES is a C-C beta chemokine with strong chemoattractant activity for T lymphocytes and monocytes. Objectives – 

The objective of our study was to find out whether IL-15 and RANTES are involved in the possible inflammatory reactions of PD. Patients and methods – 

We measured by immunoassay serum IL-15 and RANTES levels in 41 patients with PD in comparison with serum levels in 19 healthy subjects age and sex-matched. IL-15 and RANTES levels were correlated with sex, age, disease duration. H-Y stage and the UPDRS III score in all the studied groups and were also correlated with treatment status in PD patients. Results – 

The PD group presented with significantly increased RANTES levels as compared to the control group (P = 0.0009). No difference was observed as regards IL-15 levels. A strong and significant correlation between RANTES levels and UPDRS III score was observed in PD patients (Rs = 0.42, P = 0.007). Untreated patients had significantly higher RANTES levels as compared to the controls. Conclusions – 

Our findings may suggest a recruitment of activated monocytes, macrophages and T lymphocytes to sites of inflammation in the central nervous system of PD patients.

Keywords: Elisa; IL-15; L-dopa treatment; Parkinson’s disease; RANTES; immunological disturbances; serum

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0404.2007.00894.x

Affiliations: 1: Departments of Neurology 2: Biopathology-Immunology, School of Medicine, Athens National University, Aeginition Hospital, Athens, Greece

Publication date: December 1, 2007

Related content

Tools

Favourites

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more