Posterior cortical brain dysfunction in cognitively impaired patients with Parkinson’s disease – a rCBF scintigraphy study
Abstract:Wallin A, Ekberg S, Lind K, Milos V, Granérus A-K, Granerus G. Posterior cortical brain dysfunction in cognitively impaired patients with Parkinson’s disease – a rCBF scintigraphy study.
Acta Neurol Scand 2007: 116: 347–354.
© 2007 The Authors Journal compilation © 2007 Blackwell Munksgaard. Objectives –
The aim of the study was to visualize cortical function in Parkinson’s patients with various degrees of cognitive impairment. Materials and methods –
Thirty-seven patients with Parkinson’s disease and three with Parkinson plus syndromes underwent cognitive assessment and rCBF using 99mTC-HMPAO-SPECT. Results –
Almost no regional reductions in cerebral blood flow were seen in patients without cognitive impairment (n = 16). Limited, mainly posterior, blood flow reductions were seen in patients with mild cognitive impairment (n = 14), whereas the reductions were extensive and bilaterally symmetric, involving both anterior and posterior brain regions in patients with dementia (n = 10). Conclusions –
The findings suggest a widespread cortical, mainly posterior type of dysfunction and a relationship between the degree of cognitive impairment and the magnitude of the dysfunction.
Document Type: Research Article
Affiliations: 1: Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, Mölndal, Sweden 2: Division of Clinical Physiology, Section of Nuclear Medicine, IMV, Linköping University, Linköping, Sweden 3: Department of Neuroscience and Locomotion, Division of Geriatrics, Linköping University, Linköping, Sweden
Publication date: 2007-12-01