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Posterior cortical brain dysfunction in cognitively impaired patients with Parkinson’s disease – a rCBF scintigraphy study

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Abstract:

Wallin A, Ekberg S, Lind K, Milos V, Granérus A-K, Granerus G. Posterior cortical brain dysfunction in cognitively impaired patients with Parkinson’s disease – a rCBF scintigraphy study.

Acta Neurol Scand 2007: 116: 347–354.

© 2007 The Authors Journal compilation © 2007 Blackwell Munksgaard. Objectives – 

The aim of the study was to visualize cortical function in Parkinson’s patients with various degrees of cognitive impairment. Materials and methods – 

Thirty-seven patients with Parkinson’s disease and three with Parkinson plus syndromes underwent cognitive assessment and rCBF using 99mTC-HMPAO-SPECT. Results – 

Almost no regional reductions in cerebral blood flow were seen in patients without cognitive impairment (n = 16). Limited, mainly posterior, blood flow reductions were seen in patients with mild cognitive impairment (n = 14), whereas the reductions were extensive and bilaterally symmetric, involving both anterior and posterior brain regions in patients with dementia (n = 10). Conclusions – 

The findings suggest a widespread cortical, mainly posterior type of dysfunction and a relationship between the degree of cognitive impairment and the magnitude of the dysfunction.

Keywords: Alzheimer’s disease; Parkinson’s disease; SPECT; blood flow; cognitive impairment

Document Type: Research Article

DOI: https://doi.org/10.1111/j.1600-0404.2007.00887.x

Affiliations: 1: Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, Mölndal, Sweden 2: Division of Clinical Physiology, Section of Nuclear Medicine, IMV, Linköping University, Linköping, Sweden 3: Department of Neuroscience and Locomotion, Division of Geriatrics, Linköping University, Linköping, Sweden

Publication date: 2007-12-01

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