Dementia in Parkinson’s disease: diffusion tensor imaging

$48.00 plus tax (Refund Policy)

Download / Buy Article:

Abstract:

Matsui H, Nishinaka K Oda M, Niikawa H, Kubori T, Udaka F. Dementia in Parkinson’s disease: diffusion tensor imaging.

Acta Neurol Scand: 116: 177–181.

© 2007 The Authors Journal compilation © 2007 Blackwell Munksgaard. Objective – 

Dementia occurs frequently in patients with Parkinson’s disease (PD). However, the nature of the dementing process remains controversial. We evaluated various cognitive functions in patients with PD, compared fractional anisotropy (FA) values between PD patients with and without dementia. Methods – 

Thirty-seven consecutive patients with Hoehn-Yahr stage III or IV PD participated in this study. Patients were divided into two groups: (i) PD with dementia group (PDD) and (ii) PD without dementia group (PDND). There were 11 PDD and 26 PDND cases. Ten controls were also studied. Results – 

The PDD group showed significant FA reduction in the bilateral posterior cingulate bundles compared with PDND. FA values in the left posterior cingulate bundle showed significant correlations with many cognitive parameters. Interpretation – 

Our results showed that the posterior cingulate areas play some important roles in the dementing process in PDD. However, as the pathological processes responsible for dementia in PD patients may be multifaceted, further studies are necessary.

Keywords: Parkinson’s disease; cingulate bundle; dementia; diffusion tensor imaging; fractional anisotropy

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0404.2007.00838.x

Affiliations: 1: Department of Neurology, Sumitomo Hospital, Osaka, Japan 2: Department of Radiology, Sumitomo Hospital, Osaka, Japan

Publication date: September 1, 2007

Related content

Tools

Favourites

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more