Skip to main content

Neuropathological postmortem evaluation of BNCT for GBM

Buy Article:

$51.00 plus tax (Refund Policy)

Abstract:

H-Stenstam B, Pellettieri L, Sköld K, Rezaei A, Brun A. Neuropathological postmortem evaluation of BNCT for GBM.

Acta Neurol Scand: 116: 169–176.

© 2007 Hammercap Medical AB Journal compilation © 2007 Blackwell Munksgaard. Background – 

Thirty patients with glioblastoma multiforme (GBM) were treated by boron neutron capture therapy (BNCT) at the Studsvik facility in Sweden, in a clinical trial exploring a procedure in which 900 mg p-boronophenylalanine (BPA) per kilo body weight was infused in 6 h. Objective – 

The present study was designed to assess tumor efficacy and radiation damage to the brain for the seven patients in the Studsvik trial that were available for postmortem neuropathological examination. Method – 

Whole brain slices containing the initial tumor site and other regions showing pathological changes were chosen for microscopy and selected areas were studied by immunological methods. Results – 

Local control of GBM was observed in all cases. Conclusive evidence for radiation induced brain damage was not found. Conclusion – 

Using a novel procedure for BPA infusion, BNCT achieves local control of GBM for minimum tumor doses as low as 15 wGy, allowing treatment with very low concomitant doses to surrounding healthy tissues.

Keywords: boron neutron capture therapy; glioblastoma multiforme; postmortem evaluation

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0404.2007.00837.x

Affiliations: 1: Nyköping Hospital, County of Sormland 2: Hammercap Medical AB*, Stockholm 3: Department of Pathology, Lund University Hospital, Lund, Sweden

Publication date: September 1, 2007

mksg/ane/2007/00000116/00000003/art00006
dcterms_title,dcterms_description,pub_keyword
6
5
20
40
5

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more