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Long-term mortality among young ischemic stroke patients in western Norway

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Abstract:

Waje-Andreassen U, Naess H, Thomassen L, Eide GE, Vedeler CA. Long-term mortality among young ischemic stroke patients in western Norway.

Acta Neurol Scand: 116: 150–156.

©2007 The Authors Journal compilation © 2007 Blackwell Munksgaard. Objectives – 

To obtain data on long-term mortality among young ischemic stroke patients compared with controls in this population-based study. Material and methods – 

We used Kaplan–Meier survival analysis to compare 232 patients aged 15–49 years with first-ever cerebral infarction in 1988–1997 and 453 controls followed from inclusion to death or 1 August 2005 for 2515 and 5558 person-years respectively. In a subanalysis of 192 patients, we compared risk factor variables using the Kaplan–Meier method and log-rank testing. We applied a Cox proportional hazards model to adjust for multiple risk factors. Results – 

Forty-five patients and nine controls died during follow-up (P < 0.0005). Independent risk factors for mortality were active tumor disease (P < 0.0005), high consumption of alcohol (P < 0.0005), coronary atherosclerosis (P < 0.001), living alone (P < 0.02), seizures (P < 0.04) and smoking (P = 0.08). Conclusions – 

Long-term mortality was significantly increased among young stroke patients, mainly due to such lifestyle factors as high consumption of alcohol and tobacco.

Keywords: alcohol; ischemic stroke; mortality; smoking; young patients

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0404.2007.00822.x

Affiliations: Department of Neurology, Haukeland University Hospital

Publication date: September 1, 2007

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