IngentaConnect Long-term mortality among young ischemic stroke patients in weste...

Authors: Waje-Andreassen, U.¹; Naess, H.¹; Thomassen, L.¹; Eide, G. E.; Vedeler, C. A.

Source: Acta Neurologica Scandinavica, Volume 116, Number 3, September 2007 , pp. 150-156(7)

Abstract:

Waje-Andreassen U, Naess H, Thomassen L, Eide GE, Vedeler CA. Long-term mortality among young ischemic stroke patients in western Norway.

Acta Neurol Scand: 116: 150-156.

To obtain data on long-term mortality among young ischemic stroke patients compared with controls in this population-based study. Material and methods -

We used Kaplan-Meier survival analysis to compare 232 patients aged 15-49 years with first-ever cerebral infarction in 1988-1997 and 453 controls followed from inclusion to death or 1 August 2005 for 2515 and 5558 person-years respectively. In a subanalysis of 192 patients, we compared risk factor variables using the Kaplan-Meier method and log-rank testing. We applied a Cox proportional hazards model to adjust for multiple risk factors. Results -

Forty-five patients and nine controls died during follow-up (P < 0.0005). Independent risk factors for mortality were active tumor disease (P < 0.0005), high consumption of alcohol (P < 0.0005), coronary atherosclerosis (P < 0.001), living alone (P < 0.02), seizures (P < 0.04) and smoking (P = 0.08). Conclusions -

Long-term mortality was significantly increased among young stroke patients, mainly due to such lifestyle factors as high consumption of alcohol and tobacco.

Keywords: ischemic stroke; mortality; young patients; alcohol; smoking

Document Type: Research article

DOI: 10.1111/j.1600-0404.2007.00822.x

Affiliations: 1: Department of Neurology, Haukeland University Hospital

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