@article {Piechowski-Jozwiak:September 2007:0001-6314:144,
author = "Piechowski-Jozwiak, B.",
author = "Mickielewicz, A.",
author = "Gaciong, Z.",
author = "Berent, H.",
author = "Kwiecinski, H.",
title = "Elevated levels of anti-Chlamydia pneumoniae IgA and IgG antibodies in young adults with ischemic stroke",
journal = "Acta Neurologica Scandinavica",
volume = "116",
year = "September 2007",
abstract = "Piechowski-Jóźwiak B, Mickielewicz A, Gaciong Z, Berent H, Kwieciński H. Elevated levels of anti-Chlamydia pneumoniae IgA and IgG antibodies in young adults with ischemic stroke.Acta Neurol Scand: 116: 144-149.© 2007 The Authors Journal compilation © 2007 Blackwell Munksgaard. Introduction - Data on the role of Chlamydia pneumoniae in patients with ischemic stroke are inconsistent. We investigated the presence of anti-C. pneumoniae antibodies in young adults with ischemic stroke. Methods - 94 patients (<55 years) with ischemic stroke and 103 controls were enrolled. Indices of anti-C. pneumoniae IgA and IgG were assessed with an ELISA. We determined OR and 95% CI for the IgA and IgG seropositivity in stroke cases. Results - Mean IgA and IgG indices were higher in stroke patients vs controls (IgA: 1.40 vs 0.56; P < 0.001; IgG: 0.85 vs. 0.78; P < 0.003). The IgA seropositivity was associated with stroke risk (11.92; 5.94-23.92; P < 0.001) as well as IgG seropositivity was (2.31; 1.15-4.61; P < 0.016). Seropositivity assessed with combined IgA and IgG indices was associated with increased stroke risk (OR 9.35; 95% CI 4.78-18.29; P < 0.0001). After controlling for age and sex, the IgA seropositivity yielded a significantly adjusted OR for stroke (8.95; 4.44-18.07; P < 0.002), while IgG seropositivity did not (0.85; 0.53-1.63). Conclusions - We find an increased risk of stroke in young patients seropositive to C. pneumoniae in the IgA antibody class. Further studies to explore this finding are warranted.",
pages = "144-149(6)",
url = "http://www.ingentaconnect.com/content/mksg/ane/2007/00000116/00000003/art00002"
doi = "doi:10.1111/j.1600-0404.2007.00819.x"
}