Elevated levels of anti-Chlamydia pneumoniae IgA and IgG antibodies in young adults with ischemic stroke

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Abstract:

Piechowski-Jóźwiak B, Mickielewicz A, Gaciong Z, Berent H, Kwieciński H. Elevated levels of anti-Chlamydia pneumoniae IgA and IgG antibodies in young adults with ischemic stroke.

Acta Neurol Scand: 116: 144–149.

© 2007 The Authors Journal compilation © 2007 Blackwell Munksgaard. Introduction – 

Data on the role of Chlamydia pneumoniae in patients with ischemic stroke are inconsistent. We investigated the presence of anti-C. pneumoniae antibodies in young adults with ischemic stroke. Methods – 

94 patients (<55 years) with ischemic stroke and 103 controls were enrolled. Indices of anti-C. pneumoniae IgA and IgG were assessed with an ELISA. We determined OR and 95% CI for the IgA and IgG seropositivity in stroke cases. Results – 

Mean IgA and IgG indices were higher in stroke patients vs controls (IgA: 1.40 vs 0.56; P < 0.001; IgG: 0.85 vs. 0.78; P < 0.003). The IgA seropositivity was associated with stroke risk (11.92; 5.94–23.92; P < 0.001) as well as IgG seropositivity was (2.31; 1.15–4.61; P < 0.016). Seropositivity assessed with combined IgA and IgG indices was associated with increased stroke risk (OR 9.35; 95% CI 4.78–18.29; P < 0.0001). After controlling for age and sex, the IgA seropositivity yielded a significantly adjusted OR for stroke (8.95; 4.44–18.07; P < 0.002), while IgG seropositivity did not (0.85; 0.53–1.63). Conclusions – 

We find an increased risk of stroke in young patients seropositive to C. pneumoniae in the IgA antibody class. Further studies to explore this finding are warranted.

Keywords: Chlamydia pneumoniae; cerebrovascular disorders; infection; stroke

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0404.2007.00819.x

Affiliations: 1: Department of Neurology, The Medical University of Warsaw, Warsaw, Poland 2: Department of Internal Medicine and Hypertension, The Medical University of Warsaw, Warsaw, Poland

Publication date: September 1, 2007

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