IngentaConnect Oxygen metabolism changes in patients with idiopathic normal pres...

Authors: Miyamoto, J.; Tatsuzawa, K.; Inoue, Y.; Imahori, Y.; Mineura, K.

Source: Acta Neurologica Scandinavica, Volume 116, Number 3, September 2007 , pp. 137-143(7)

Abstract:

Miyamoto J, Tatsuzawa K, Inoue Y, Imahori Y, Mineura K. Oxygen metabolism changes in patients with idiopathic normal pressure hydrocephalus before and after shunting operation.

Acta Neurol Scand: 116: 137-143.

The present study revealed the changes in cerebral oxygen metabolism before and after ventriculo-peritoneal shunt (VPS) using ¹⁵O positron emission tomography (¹⁵O-PET). Methods -

Eight patients with idiopathic normal pressure hydrocephalus (i-NPH) underwent VPS. A ¹⁵O-PET study was undertaken before and approximately 3 months after VPS. In five patients, the symptoms improved based on the classification by Krauss et al. [Neurosurgery 1996;39:292] (good responders) after VPS. In three patients, the symptoms improved subjectively following VPS (poor responders). The changes in oxygen metabolism before and after VPS were analyzed. Results -

The postoperative regional cerebral metabolic rate of oxygen (rCMRO₂) of the good responders increased significantly. The postoperative regional oxygen extraction fraction (rOEF) is reduced in the poor responders. Conclusion -

The improvement of rCMRO₂ correlated with the response to VPS. Significant changes in rOEF might predict poor response to VPS.

Keywords: idiopathic normal pressure hydrocephalus; oxygen metabolism; positron emission tomography

Document Type: Research article

DOI: 10.1111/j.1600-0404.2007.00798.x

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