Skip to main content

Oxygen metabolism changes in patients with idiopathic normal pressure hydrocephalus before and after shunting operation

Buy Article:

$51.00 plus tax (Refund Policy)

Abstract:

Miyamoto J, Tatsuzawa K, Inoue Y, Imahori Y, Mineura K. Oxygen metabolism changes in patients with idiopathic normal pressure hydrocephalus before and after shunting operation.

Acta Neurol Scand: 116: 137–143.

© 2007 The Authors Journal compilation © 2007 Blackwell Munksgaard. Objective – 

The present study revealed the changes in cerebral oxygen metabolism before and after ventriculo-peritoneal shunt (VPS) using 15O positron emission tomography (15O-PET). Methods – 

Eight patients with idiopathic normal pressure hydrocephalus (i-NPH) underwent VPS. A 15O-PET study was undertaken before and approximately 3 months after VPS. In five patients, the symptoms improved based on the classification by Krauss et al. [Neurosurgery 1996;39:292] (good responders) after VPS. In three patients, the symptoms improved subjectively following VPS (poor responders). The changes in oxygen metabolism before and after VPS were analyzed. Results – 

The postoperative regional cerebral metabolic rate of oxygen (rCMRO2) of the good responders increased significantly. The postoperative regional oxygen extraction fraction (rOEF) is reduced in the poor responders. Conclusion – 

The improvement of rCMRO2 correlated with the response to VPS. Significant changes in rOEF might predict poor response to VPS.

Keywords: idiopathic normal pressure hydrocephalus; oxygen metabolism; positron emission tomography

Document Type: Research Article

DOI: https://doi.org/10.1111/j.1600-0404.2007.00798.x

Publication date: 2007-09-01

  • Access Key
  • Free ContentFree content
  • Partial Free ContentPartial Free content
  • New ContentNew content
  • Open Access ContentOpen access content
  • Partial Open Access ContentPartial Open access content
  • Subscribed ContentSubscribed content
  • Partial Subscribed ContentPartial Subscribed content
  • Free Trial ContentFree trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more