Skip to main content

Oxygen metabolism changes in patients with idiopathic normal pressure hydrocephalus before and after shunting operation

Buy Article:

$43.00 plus tax (Refund Policy)

Miyamoto J, Tatsuzawa K, Inoue Y, Imahori Y, Mineura K. Oxygen metabolism changes in patients with idiopathic normal pressure hydrocephalus before and after shunting operation.

Acta Neurol Scand: 116: 137–143.

© 2007 The Authors Journal compilation © 2007 Blackwell Munksgaard. Objective – 

The present study revealed the changes in cerebral oxygen metabolism before and after ventriculo-peritoneal shunt (VPS) using 15O positron emission tomography (15O-PET). Methods – 

Eight patients with idiopathic normal pressure hydrocephalus (i-NPH) underwent VPS. A 15O-PET study was undertaken before and approximately 3 months after VPS. In five patients, the symptoms improved based on the classification by Krauss et al. [Neurosurgery 1996;39:292] (good responders) after VPS. In three patients, the symptoms improved subjectively following VPS (poor responders). The changes in oxygen metabolism before and after VPS were analyzed. Results – 

The postoperative regional cerebral metabolic rate of oxygen (rCMRO2) of the good responders increased significantly. The postoperative regional oxygen extraction fraction (rOEF) is reduced in the poor responders. Conclusion – 

The improvement of rCMRO2 correlated with the response to VPS. Significant changes in rOEF might predict poor response to VPS.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: idiopathic normal pressure hydrocephalus; oxygen metabolism; positron emission tomography

Document Type: Research Article

Publication date: 2007-09-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more