Oxygen metabolism changes in patients with idiopathic normal pressure hydrocephalus before and after shunting operation
Abstract:Miyamoto J, Tatsuzawa K, Inoue Y, Imahori Y, Mineura K. Oxygen metabolism changes in patients with idiopathic normal pressure hydrocephalus before and after shunting operation.
Acta Neurol Scand: 116: 137–143.
© 2007 The Authors Journal compilation © 2007 Blackwell Munksgaard. Objective –
The present study revealed the changes in cerebral oxygen metabolism before and after ventriculo-peritoneal shunt (VPS) using 15O positron emission tomography (15O-PET). Methods –
Eight patients with idiopathic normal pressure hydrocephalus (i-NPH) underwent VPS. A 15O-PET study was undertaken before and approximately 3 months after VPS. In five patients, the symptoms improved based on the classification by Krauss et al. [Neurosurgery 1996;39:292] (good responders) after VPS. In three patients, the symptoms improved subjectively following VPS (poor responders). The changes in oxygen metabolism before and after VPS were analyzed. Results –
The postoperative regional cerebral metabolic rate of oxygen (rCMRO2) of the good responders increased significantly. The postoperative regional oxygen extraction fraction (rOEF) is reduced in the poor responders. Conclusion –
The improvement of rCMRO2 correlated with the response to VPS. Significant changes in rOEF might predict poor response to VPS.