Authors: Anckarsäter, R.¹; Vasic, N.¹; Jidéus, L.²; Kristiansson, M.³; Zetterberg, H.⁴; Blennow, K.⁴; Anckarsäter, H.⁵

Source: Acta Neurologica Scandinavica, Volume 115, Number 4, April 2007 , pp. 254-259(6)

Publisher: Wiley-Blackwell

Abstract:

Anckarsäter R, Vasic N, Jidéus L, Kristiansson M, Zetterberg H, Blennow K, Anckarsäter H. Cerebrospinal fluid protein reactions during non-neurological surgery. Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2006.00741.x. © Blackwell Munksgaard 2006. Objective - 

To study changes in cerebrospinal fluid (CSF) protein markers of blood-CSF barrier integrity and immunological reactions during surgical stress. Subjects and methods - 

Thirty-five patients without neurological or psychiatric disorders undergoing knee replacements had CSF and serum samples drawn from spinal and arterial catheters before, 3 h after and the morning after surgery. Results - 

Serum albumin decreased during surgery and CSF albumin decreased during and after surgery, and, as a consequence, the CSF/serum albumin ratio decreased significantly during the study period, especially after the intervention. In contrast, CSF concentrations of beta-2-microglobuline (β2M) increased significantly during surgery and remained high. The CSF general marker beta-trace protein (βTP) remained unchanged. Conclusions - 

Central nervous system protein reactions to a non-neurological surgical intervention include sharply decreased permeability of albumin into the CSF and signs of intrathecal inflammatory activity.

Keywords: albumin; beta-2-microglobuline; blood-brain barrier; cerebrospinal fluid; inflammation; spinal anaesthesia; stress

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1600-0404.2006.00741.x

Affiliations: 1: Department of Anaesthesiology and Intensive Care, Kungälv Hospital, Kungälv 2: Institute of Surgical Sciences, Uppsala University, Uppsala 3: Neurotec, Karolinska Institutet, Stockholm 4: Institute of Clinical Neuroscience, Göteborg University, Göteborg 5: Institute of Clinical Sciences, Malmö University Hospital, Lund University, Lund, Sweden

Publication date: 2007-04-01

Related content

• In this: publication
• By this: publisher
• In this Subject: Neurology & Psychiatry
• By this author: Anckarsäter, R. ;  Vasic, N. ;  Jidéus, L. ;  Kristiansson, M. ;  Zetterberg, H. ;  Blennow, K. ;  Anckarsäter, H.

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers