IngentaConnect Cerebrospinal fluid protein reactions during non-neurological sur...

Authors: Anckarsäter, R.¹; Vasic, N.¹; Jidéus, L.²; Kristiansson, M.³; Zetterberg, H.⁴; Blennow, K.⁴; Anckarsäter, H.⁵

Source: Acta Neurologica Scandinavica, Volume 115, Number 4, April 2007 , pp. 254-259(6)

Publisher: Blackwell Publishing

Abstract:

Anckarsäter R, Vasic N, Jidéus L, Kristiansson M, Zetterberg H, Blennow K, Anckarsäter H. Cerebrospinal fluid protein reactions during non-neurological surgery. Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2006.00741.x. © Blackwell Munksgaard 2006. Objective -

To study changes in cerebrospinal fluid (CSF) protein markers of blood-CSF barrier integrity and immunological reactions during surgical stress. Subjects and methods -

Thirty-five patients without neurological or psychiatric disorders undergoing knee replacements had CSF and serum samples drawn from spinal and arterial catheters before, 3 h after and the morning after surgery. Results -

Serum albumin decreased during surgery and CSF albumin decreased during and after surgery, and, as a consequence, the CSF/serum albumin ratio decreased significantly during the study period, especially after the intervention. In contrast, CSF concentrations of beta-2-microglobuline (β2M) increased significantly during surgery and remained high. The CSF general marker beta-trace protein (βTP) remained unchanged. Conclusions -

Central nervous system protein reactions to a non-neurological surgical intervention include sharply decreased permeability of albumin into the CSF and signs of intrathecal inflammatory activity.

Keywords: albumin; beta-2-microglobuline; blood-brain barrier; cerebrospinal fluid; inflammation; spinal anaesthesia; stress

Document Type: Research article

DOI: 10.1111/j.1600-0404.2006.00741.x

Affiliations: 1: Department of Anaesthesiology and Intensive Care, Kungälv Hospital, Kungälv 2: Institute of Surgical Sciences, Uppsala University, Uppsala 3: Neurotec, Karolinska Institutet, Stockholm 4: Institute of Clinical Neuroscience, Göteborg University, Göteborg 5: Institute of Clinical Sciences, Malmö University Hospital, Lund University, Lund, Sweden

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$50.16 plus tax Refund Policy