@article {Hogh:April 2007:0001-6314:248,
author = "Hogh, P.",
author = "Garde, E.",
author = "Mortensen, E. L.",
author = "Jorgensen, O. S.",
author = "Krabbe, K.",
author = "Waldemar, G.",
title = "The apolipoprotein E 4-allele and antihypertensive treatment are associated with increased risk of cerebral MRI white matter hyperintensities",
journal = "Acta Neurologica Scandinavica",
volume = "115",
year = "April 2007",
abstract = "Høgh P, Garde E, Mortensen EL, Jørgensen OS, Krabbe K, Waldemar G. The apolipoprotein E ɛ4-allele and antihypertensive treatment are associated with increased risk of cerebral MRI white matter hyperintensities. Acta Neurol Scand: DOI:10.1111/j.1600-0404.2006.00779.x © 2007 The Authors Journal compilation © 2007 Blackwell Munksgaard. Objective - Apolipoprotein E-ɛ4 (APOE-ɛ4) is a potential risk factor for cerebral vascular disease. The aim of the present study was to examine the relative importance of APOE-ɛ4 and other relevant risk factors for the extent of cerebral white matter hyperintensity (WMH) in a community-based sample of elderly subjects. Materials and methods - From a cohort of 976 subjects born in 1914, APOE genotype was determined and MRI examinations were carried out in 75 subjects. WMH were rated using a standard semi-quantitative method. ANOVA and regression analyses were conducted to explore the relative importance of the potential risk factors. Results - APOE genotype and antihypertensive treatment were significantly associated with severity of total WMH load (P < 0.05). Conclusions - The study confirmed the association between APOE-ɛ4 and WMH. Pharmaceutical treatment for arterial hypertension was also associated with the total burden of WMH in this study.",
pages = "248-253(6)",
url = "http://www.ingentaconnect.com/content/mksg/ane/2007/00000115/00000004/art00005"
doi = "doi:10.1111/j.1600-0404.2006.00779.x"
}