IngentaConnect The apolipoprotein E 4-allele and antihypertensive treatment are ...

Authors: Høgh, P.¹; Garde, E.; Mortensen, E. L.; Jørgensen, O. S.²; Krabbe, K.³; Waldemar, G.¹

Source: Acta Neurologica Scandinavica, Volume 115, Number 4, April 2007 , pp. 248-253(6)

Abstract:

Høgh P, Garde E, Mortensen EL, Jørgensen OS, Krabbe K, Waldemar G. The apolipoprotein E ɛ4-allele and antihypertensive treatment are associated with increased risk of cerebral MRI white matter hyperintensities. Acta Neurol Scand: DOI:10.1111/j.1600-0404.2006.00779.x © 2007 The Authors Journal compilation © 2007 Blackwell Munksgaard. Objective -

Apolipoprotein E-ɛ4 (APOE-ɛ4) is a potential risk factor for cerebral vascular disease. The aim of the present study was to examine the relative importance of APOE-ɛ4 and other relevant risk factors for the extent of cerebral white matter hyperintensity (WMH) in a community-based sample of elderly subjects. Materials and methods -

From a cohort of 976 subjects born in 1914, APOE genotype was determined and MRI examinations were carried out in 75 subjects. WMH were rated using a standard semi-quantitative method. ANOVA and regression analyses were conducted to explore the relative importance of the potential risk factors. Results -

APOE genotype and antihypertensive treatment were significantly associated with severity of total WMH load (P < 0.05). Conclusions -

The study confirmed the association between APOE-ɛ4 and WMH. Pharmaceutical treatment for arterial hypertension was also associated with the total burden of WMH in this study.

Keywords: APOE; MRI; WMH; arterial hypertension; cerebrovascular

Document Type: Research article

DOI: 10.1111/j.1600-0404.2006.00779.x

Affiliations: 1: Memory Disorders Research Unit, The Neuroscience Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark 2: Laboratory of Neuropsychiatry, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark 3: Department of Pharmacology, Danish Research Centre of Magnetic Resonance, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark

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