ACE I/D polymorphism in different etiologies of ischemic stroke

Authors: Pera, J.; Slowik, A.; Dziedzic, T.; Wloch, D.; Szczudlik, A.

Source: Acta Neurologica Scandinavica, Volume 114, Number 5, November 2006 , pp. 320-322(3)

Publisher: Wiley-Blackwell

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Abstract:

Pera J, Slowik A, Dziedzic T, Wloch D, Szczudlik A. ACE I/D polymorphism in different etiologies of ischemic stroke.

Acta Neurol Scand 2006: 114: 320-322 © Blackwell Munksgaard 2006. Objectives -

Data concerning an association between angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and ischemic stroke (IS) remain inconsistent. Results of some studies suggest that DD genotype may be a risk factor for small vessel disease (SVD) stroke. Here, we investigated whether this polymorphism is associated with IS of different etiologies in a Polish population. Subjects and methods -

Ischemic stroke etiology was established according to the TOAST criteria. We studied 92 stroke patients with large vessel disease and their 184 matched controls; 96 stroke patients with SVD and 192 controls; 180 patients with cardioembolic stroke (CE) and 180 controls. ACE I/D polymorphism was determined using the polymerase chain reaction method. Results -

The distribution of ACE genotypes and alleles was essentially the same in all analyzed IS subtypes and their matched controls. Conclusions -

We failed to find an association between ACE polymorphism and etiological subtypes of IS in a Polish population.

Keywords: ACE I/D polymorphism; cardioembolism; etiology; genetics; large vessel disease; small vessel disease; stroke

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1600-0404.2006.00672.x

Publication date: 2006-11-01