ApoE genotype and cognition after subarachnoid haemorrhage: a longitudinal study

Authors: Louko, A.-M.; Vilkki, J.; Niskakangas, T.

Source: Acta Neurologica Scandinavica, Volume 114, Number 5, November 2006 , pp. 315-319(5)

Publisher: Wiley-Blackwell

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Abstract:

Louko A-M, Vilkki J, Niskakangas T. ApoE genotype and cognition after subarachnoid haemorrhage: a longitudinal study.

Acta Neurol Scand 2006: 114: 315-319. © Blackwell Munksgaard 2006. Objectives -

To investigate the effect of the apolipoprotein ɛ4 allele on cognitive functions after aneurysmal subarachnoid haemorrhage (SAH) in a longitudinal study. Materials and methods -

Performances of 19 patients with and 27 patients without the ɛ4 allele were compared on eight cognitive test variables measured 1-4.5 years and 12-15 years after SAH. Results -

In the baseline examination, ɛ4 patients scored worse than non-ɛ4 patients on verbal fluency (P < 0.05). In the follow-up, a visual memory task and interference in colour naming showed more pronounced impairments from baseline in ɛ4 carriers than in non-carriers. Conclusion -

Presence of the ɛ4 allele poses a minor risk for late cognitive impairment after the subacute phase of aneurysmal SAH.

Keywords: apolipoprotein E; cognition; longitudinal study; subarachnoid haemorrhage

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1600-0404.2006.00676.x

Publication date: 2006-11-01