Diagnostic yield of prothrombotic state studies in cryptogenic stroke

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Abstract:

Belvís R, Santamaría A, Martí-Fàbregas J, Cocho D, Borrell M, Fontcuberta J, Martí-Vilalta JL. Diagnostic yield of prothrombotic state studies in cryptogenic stroke.

Acta Neurol Scand 2006: 114: 250–253.

© 2006 The Authors Journal compilation 2006 Blackwell Munksgaard. Objectives – 

Around 30% of ischemic strokes are considered cryptogenic. We analyzed the diagnostic yield of prothrombotic state (PS) studies in patients with an initial cryptogenic stroke (CS). Material and methods – 

We prospectively included consecutive CS patients according to the TOAST criteria. PS included plasmatic determinations of antiphospholipid (APL) antibodies and lupus anticoagulant (LA), S (SPd) and C (CPd) protein deficiencies, and genetic analysis of the prothrombin gene mutation (PTG20210A) and the factor V Leiden mutation (FVG1691A). We recorded age, sex and vascular risk factors. Results – 

From a total of 89 patients (mean age 56.9 ± 14.3 years, 53% men), we identified 16 PS in 15 patients (16.85%): APL-6, LA-2, SPd-2, CPd-1, PTG20210A-3 and FVG1691A-2. One patient presented an association (APL and PTG20210A). Conclusions – 

One of every six patients with initial CS present a PS. Age or sex and conventional cardiovascular risk factors were not related to PS study findings, supporting the relevance of such studies in all patients with an initial CS.

Keywords: Leiden; antiphospholipid; cryptogenic stroke; prothrombin; prothrombotic state

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0404.2006.00588.x

Affiliations: 1: Stroke Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain 2: Haemostasis and Thrombosis Unit, Department of Haematology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain

Publication date: October 1, 2006

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