Skip to main content

Diagnostic yield of prothrombotic state studies in cryptogenic stroke

Buy Article:

$43.00 plus tax (Refund Policy)

Belvís R, Santamaría A, Martí-Fàbregas J, Cocho D, Borrell M, Fontcuberta J, Martí-Vilalta JL. Diagnostic yield of prothrombotic state studies in cryptogenic stroke.

Acta Neurol Scand 2006: 114: 250–253.

© 2006 The Authors Journal compilation 2006 Blackwell Munksgaard. Objectives – 

Around 30% of ischemic strokes are considered cryptogenic. We analyzed the diagnostic yield of prothrombotic state (PS) studies in patients with an initial cryptogenic stroke (CS). Material and methods – 

We prospectively included consecutive CS patients according to the TOAST criteria. PS included plasmatic determinations of antiphospholipid (APL) antibodies and lupus anticoagulant (LA), S (SPd) and C (CPd) protein deficiencies, and genetic analysis of the prothrombin gene mutation (PTG20210A) and the factor V Leiden mutation (FVG1691A). We recorded age, sex and vascular risk factors. Results – 

From a total of 89 patients (mean age 56.9 ± 14.3 years, 53% men), we identified 16 PS in 15 patients (16.85%): APL-6, LA-2, SPd-2, CPd-1, PTG20210A-3 and FVG1691A-2. One patient presented an association (APL and PTG20210A). Conclusions – 

One of every six patients with initial CS present a PS. Age or sex and conventional cardiovascular risk factors were not related to PS study findings, supporting the relevance of such studies in all patients with an initial CS.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Leiden; antiphospholipid; cryptogenic stroke; prothrombin; prothrombotic state

Document Type: Research Article

Affiliations: 1: Stroke Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain 2: Haemostasis and Thrombosis Unit, Department of Haematology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain

Publication date: 01 October 2006

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more