Subclinical left ventricular dysfunction in multiple sclerosis
Abstract:Akgül F, Mclek İ, Duman T, Seyfelì E, Seydaliyeva T, Yalçın F. Subclinical left ventricular dysfunction in multiple sclerosis.
Acta Neurol Scand 2006: 114: 114–118. © 2006 Blackwell Munksgaard. Objectives –
To investigate the left (LV) and right ventricular (RV) function in multiple sclerosis (MS) using standard echocardiography and Doppler tissue imaging (DTI). Materials and methods –
A total of 41 patients with definite MS and 32 healthy controls were included in the study. Results –
LV end-systolic dimension was increased and LV ejection fraction was decreased in MS patients compared with controls (P<0.05). LV end-diastolic dimension was increased in MS patients, however, did not reach significance. Among DTI parameters, mitral annular peak early diastolic velocity to peak late diastolic velocity ratio (Em/Am) was decreased in MS patients, but not reach statistical significance. No significant differences in tricuspid annular Em/Am ratio was found between MS patients and controls. A statistically significant increase of DTI derived LV myocardial performance index was found in MS patients as compared with controls. RV myocardial performance index showed a tendency to be increased in MS patients, however, did not reach significance. Conclusions –
These findings suggest subclinical LV dysfunction and preserved RV function in patients with MS.
Document Type: Research Article
Publication date: 2006-08-01