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Subclinical left ventricular dysfunction in multiple sclerosis

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Abstract:

Akgül F, Mclek İ, Duman T, Seyfelì E, Seydaliyeva T, Yalçın F. Subclinical left ventricular dysfunction in multiple sclerosis.

Acta Neurol Scand 2006: 114: 114–118. © 2006 Blackwell Munksgaard. Objectives – 

To investigate the left (LV) and right ventricular (RV) function in multiple sclerosis (MS) using standard echocardiography and Doppler tissue imaging (DTI). Materials and methods – 

A total of 41 patients with definite MS and 32 healthy controls were included in the study. Results – 

LV end-systolic dimension was increased and LV ejection fraction was decreased in MS patients compared with controls (P<0.05). LV end-diastolic dimension was increased in MS patients, however, did not reach significance. Among DTI parameters, mitral annular peak early diastolic velocity to peak late diastolic velocity ratio (Em/Am) was decreased in MS patients, but not reach statistical significance. No significant differences in tricuspid annular Em/Am ratio was found between MS patients and controls. A statistically significant increase of DTI derived LV myocardial performance index was found in MS patients as compared with controls. RV myocardial performance index showed a tendency to be increased in MS patients, however, did not reach significance. Conclusions – 

These findings suggest subclinical LV dysfunction and preserved RV function in patients with MS.

Keywords: Multiple sclerosis; tissue doppler; ventricular function

Document Type: Research Article

DOI: https://doi.org/10.1111/j.1600-0404.2006.00662.x

Affiliations: 1: Mustafa Kemal University, Faculty of Medicine, Department of Cardiology, Antakya, Turkey 2: Mustafa Kemal University, Faculty of Medicine, Department of Neurology, Antakya, Turkey

Publication date: 2006-08-01

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