Preclinical evidence of Alzheimer changes in progressive mild cognitive impairment: a qualitative and quantitative SPECT study
Abstract:Ishiwata A, Sakayori O, Minoshima S, Mizumura S, Kitamura S, Katayama Y. Preclinical evidence of Alzheimer changes in progressive mild cognitive impairment: a qualitative and quantitative SPECT study.
Acta Neurol Scand 2006: 114: 91–96. © 2006 The Authors Journal compilation © 2006 Blackwell Munksgaard. Objectives –
Baseline brain single-photon emission computed tomography (SPECT) can predict mild cognitive impairment (MCI) patients at risk for progressive MCI (PMCI). Methods –
Twenty-eight subjects [12 MCI, 6 with probable Alzheimer's Disease (AD), and 10 normal subjects] underwent baseline brain SPECT and were clinically followed for a mean period of 36 months. Results –
Of 12 MCI patients, 6 progressed to PMCI and 6 remained stable. Baseline SPECT identified asymmetric perfusion reduction in the parahippocampus (−5%), lateral parietal (−8%), and posterior cingulate (−11%) cortices – reductions consistent with that of mild AD – in five of the six PMCI patients. Significant perfusion reduction was observed particularly in the frontal cortices of probable AD when compared with PMCI (P < 0.05). Conclusion –
Baseline SPECT can identify brain perfusion abnormalities among patients with MCI for progression to PMCI. This imaging modality may aid in MCI treatment stratification.
Document Type: Research Article
Affiliations: 1: Department of Neurology, Nippon Medical School, Tokyo, Japan 2: Department of Radiology, University of Washington, Seattle, WA, USA 3: Department of Radiology, Nippon Medical School, Tokyo, Japan
Publication date: 2006-08-01