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Relation between vascular risk factors and cognition at age 75

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Fischer P, Zehetmayer S, Bauer K, Huber K, Jungwirth S, Tragl K-H. Relation between vascular risk factors and cognition at age 75.

Acta Neurol Scand 2006: 114: 84–90. © 2006 The Authors Journal compilation © 2006 Blackwell Munksgaard. Objective – 

Recent trends in dementia research emphasize that not only cerebrovascular events but also vascular risk factors induce, favour or cause cognitive impairment and Alzheimer's disease. Material and methods – 

We evaluated vascular risk factors (blood pressure, LDL cholesterol, HDL cholesterol, triglycerides, HbA1c, homocysteine, lipoprotein(a), fibrinogen, C-reactive protein and smoking habits) in a community-based cohort of 75-year-old individuals of two districts in Vienna (247 men, 359 women) and correlated these risk factors with overall cognition. Results – 

Pathological vascular risk factors were found frequently in the age cohort. However, the expected associations between the Mini-Mental State Examination and any cardiovascular risk factors were missing. Only individuals with a positive history of smoking showed lower cognitive capacities. Conclusions – 

We assume that cognitive dysfunction in old age is connected to factors other than the known classical and novel risk factors for the development of cardiovascular disease.
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Keywords: cognition; dementia; smoking; vascular risk factors

Document Type: Research Article

Affiliations: 1: Ludwig Boltzmann Society, L. Boltzmann Institute of Aging Research & Department of General Psychiatry, Medical University of Vienna, Vienna, Austria 2: Institute for Medical Statistics, Medical University of Vienna, Vienna, Austria 3: Ludwig Boltzmann Society, L. Boltzmann Institute of Molecular Genetic Laboratory, Danube Hospital, Vienna, Austria 4: Ludwig Boltzmann Society, L. Boltzmann Institute of Aging Research, Vienna, Austria

Publication date: 2006-08-01

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