Autopsy findings in the nervous system and ovarian tumour of two patients with paraneoplastic cerebellar degeneration

Authors: Storstein, A.; Krossnes, B.; Vedeler, C. A.

Source: Acta Neurologica Scandinavica, Volume 113, Supplement 183, May 2006 , pp. 69-70(2)

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Abstract:

Storstein A, Krossnes B, Vedeler CA. Autopsy findings in the nervous system and ovarian tumour of two patients with paraneoplastic cerebellar degeneration. Acta Neurol Scand 2006: 113 (Suppl. 183) : 69–70. © 2006 The Authors. Journal compilation © 2006 Blackwell Munksgaard. Objectives.

To review autopsy findings in paraneoplastic cerebellar degeneration. Materials and methods.

We report the autopsy results of two individuals with paraneoplastic cerebellar degeneration and ovarian cancer. Results.

Both patients had extensive loss of cerebellar Purkinje cells and general activation of microglia in the central nervous system, as well as signs of immunactivation in the medulla. Conclusion.

The immunoactivation in PCD is widespread and involving more than the cerebellum.

Keywords: cerebellar degeneration; paraneoplasia; ovarian cancer; autopsy

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1600-0404.2006.00621.x

Publication date: 2006-05-01