@article {Bosche:June 2006:0001-6314:433,
author = "Bosche, B.",
author = "Dohmen, C.",
author = "Impekoven, P.",
author = "Weber, O. Z.",
author = "Reske, D.",
author = "Rubbert, A.",
author = "Jacobs, A. H.",
author = "Petereit, H.-F.",
title = "Stroke after initiation of interferon-beta treatment for relapsingremitting disseminated white matter disease",
journal = "Acta Neurologica Scandinavica",
volume = "113",
year = "June 2006",
abstract = "Bosche B, Dohmen C, Impekoven P, Weber OZ, Reske D, Rubbert A, Jacobs AH, Petereit H-F. Stroke after initiation of interferon beta treatment for relapsing–remitting disseminated white matter disease.Acta Neurol Scand 2006: 113: 433–436.© Blackwell Munksgaard 2006. Background – Interferon-beta (INF-β) is effective and used in reducing exacerbation frequency and disease progression in multiple sclerosis. In certain circumstances, INF-β can lead to rare side effects. Aims of the study – We report the case of a 34-year-old female patient satisfying the McDonald criteria of multiple sclerosis without showing typical pathologic changes in cerebrospinal fluid (CSF). After introduction of INF-β treatment, she quickly developed further progression of her disseminated neurological symptoms and finally an ischemic cerebral infarction. Methods – Evaluation of the patient included arterial angiography, magnetic resonance and positron emission tomography, histopathological assessment as well as a broad spectrum of serum and CSF analysis. Results – All diagnostic evaluations and the clinical course revealed evidences for a primary angiitis of the CNS. We discuss the possible worsening due to inappropriate INF-β treatment in cerebral angiitis promoting severe cerebrovascular insufficiency. Conclusion – The authors suggest that all diagnostic multiple sclerosis criteria including typical CSF findings should be ascertained before INF-β treatment is initiated.",
pages = "433-436(4)",
url = "http://www.ingentaconnect.com/content/mksg/ane/2006/00000113/00000006/art00013"
doi = "doi:10.1111/j.1600-0404.2006.00638.x"
}