IngentaConnect A prospective PET study of patients with glioblastoma multiforme

Authors: Andersen, P. B.; Blinkenberg, M.; Lassen, U.¹; Kosteljanetz, M.²; Wagner, A.³; Poulsen, H. S.¹; Sørensen, P. S.⁴; Paulson, O. B.

Source: Acta Neurologica Scandinavica, Volume 113, Number 6, June 2006 , pp. 412-418(7)

Publisher: Blackwell Publishing

Abstract:

Andersen PB, Blinkenberg M, Lassen U, Kosteljanetz M, Wagner A, Poulsen HS, Sørensen PS, Paulson OB. A prospective PET study of patients with glioblastoma multiforme.

Acta Neurol Scand 2006: 113: 412–418.

To study the post-surgical metabolic and structural cerebral changes in patients with glioblastoma multiforme (GBM). Materials and methods –

We examined ten patients prospectively with newly diagnosed GBM. All patients were primarily treated with surgery, followed by chemotherapy (carmustine, cisplatine and etoposide) and radiotherapy. Positron emission tomography (PET) was used to measure tumor- and cerebral metabolism. CT or MRI was used to estimate tumor volume by measurements of tumor area. Results –

Tumor metabolism was not increased during chemotherapy (P = 0.71), but increased during radiotherapy (P = 0.01). CT/MRI showed similar results with no increase in tumor area during chemotherapy (P = 0.33) but increase during radiotherapy (P = 0.002). During the entire study, tumor metabolism and area increased evenly (P = 0.01). Conclusions –

Our study did not show a gain of PET compared with structural imaging in the prospective evaluation of GBM. We found a difference in metabolic increase and tumor growth between the two treatment regimens, although this finding has limited relevance due to the design of the study.

Keywords: brain tumor; chemotherapy; glioblastoma multiforme; neurooncology; PET, positron emission tomography; prospective study; radiotherapy

Document Type: Research article

DOI: 10.1111/j.1600-0404.2006.00628.x

Affiliations: 1: Department of Oncology, Section for Neuro-Oncology, The Finsen Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark 2: Neurosurgery 3: Department of Neuroradiology 4: Departments of Neurology

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