Authors: Singh, G.; Singh, P.; Singh, I.¹; Rani, A.²; Kaushal, S.; Avasthi, G.¹

Source: Acta Neurologica Scandinavica, Volume 113, Number 4, April 2006 , pp. 233-240(8)

Publisher: Wiley-Blackwell

Abstract:

Singh G, Singh P, Singh I, Rani A, Kaushal S, Avasthi G. Epidemiologic classification of seizures associated with neurocysticercosis: observations from a sample of seizure disorders in neurologic care in India. Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2005.00575.x.

© 2006 The Authors Journal compilation © 2006 Blackwell Munksgaard. Aims – 

To determine the etiologic role of neurocysticercosis (NC) in a hospital-based sample of epilepsies divided according to International League Against Epilepsy (ILAE) epidemiological criteria and number of seizures prior to presentation. Methods – 

A sample comprising 1026 consecutive patients with either definite seizures or epilepsy attending a Neurology Outpatient Service was divided into four subgroups: single seizure (n = 314), incident epilepsy (n = 127), prevalent epilepsy (n = 398) and recurrent acute symptomatic seizures (RASS) (n = 175). The etiologic contribution of NC to each of the subgroups was examined with imaging studies. Results – 

Neurocysticercosis was diagnosed on imaging studies in 34.6% of patients with seizure disorder of any type, 59.2% of those with a single seizure, 23.7% of those with recurrent seizure disorder, 92.0% of those with RASS, none of cases of incident epilepsy and 2.0% with prevalent epilepsy. A diagnosis of NC was significantly associated with single seizures (P < 0.001). Conclusions – 

Imaging abnormalities consistent with NC are frequently noted in persons presenting with a single seizure in neurologic care in NC-endemic countries like India. The probability of diagnosing NC diminishes with increasing numbers of seizures. Among samples of individuals with recurrent-unprovoked seizures, it is rare for imaging to demonstrate lesions of NC.

Keywords: neurocysticercosis; seizures; epilepsy; acute symptomatic seizures

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1600-0404.2005.00575.x

Affiliations: 1: Department of Internal Medicine 2: Department of Neurology

Publication date: 2006-04-01

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