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Patient satisfaction with an injection device for multiple sclerosis treatment

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Cramer JA, Cuffel BJ, Divan V, Al-Sabbagh A, Glassman M. Patient satisfaction with an injection device for multiple sclerosis treatment.

Acta Neurol Scand 2006: 113: 156–162 © 2006 The Authors Journal compilation © 2006 Blackwell Munksgaard. Objectives – 

To develop a measure of treatment satisfaction assessing attributes specific to injected interferon-beta-1a (IFN-β-1a) for multiple sclerosis (MS), and to test pain and instrument sensitivity to change among patients changing injection devices. Materials and methods – 

The MS Treatment Concerns Questionnaire (MSTCQ) was developed and tested with pain assessments before and 3 months after patients changed devices from Rebiject to Rebiject II. Results – 

The MSTCQ was organized with two domains: Injection System Satisfaction and Side Effects (three subscales: Injection Site Reactions, Global Satisfaction, and Flu-Like Symptoms). Significant improvements (P = 0.002 to P < 0.001) occurred with the new injection device in all MSTCQ subscales (except Flu-Like Symptoms), and all pain measures (P < 0.0001). Clinically meaningful improvement was demonstrated in all scales, except Flu-Like Symptoms, by effect sizes (0.23–0.59). Conclusions – 

These statistically significant and clinically meaningful improvements in MSTCQ and pain measures show the value of technologically advanced devices in domains of concern to patients.
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Keywords: interferon-beta-1a; multiple sclerosis; pain; treatment satisfaction

Document Type: Research Article

Affiliations: 1: Department of Psychiatry, Yale University, New Haven, CT, USA 2: Outcomes Research, Pfizer Inc., New York, NY, USA 3: Medical Regulatory Services, Pfizer Inc., New York, NY, USA 4: Medical Affairs Department, Serono S.A., Rockland, MA, USA 5: Statistical Consultant, New York, NY, USA

Publication date: 2006-03-01

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