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Epileptogenesis and rational therapeutic strategies

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Stefan H, Lopes da Silva FH, Löscher W, Schmidt D, Perucca E, Brodie MJ, Boon PAJM, Theodore WH, Moshé SL. Epileptogenesis and rational therapeutic strategies.

Acta Neurol Scand 2006: 113: 139–155. © 2006 The Authors Journal compilation © 2006 Blackwell Munksgaard.

The understanding of neurobiological mechanisms of epileptogenesis is essential for rational approaches for a possible disease modification as well as treatment of underlying causes of the epilepsies. More effort is necessary to translate results from basic investigations into new approaches for clinical research and to better understand a relationship with findings from clinical studies. The following report is a condensed synapsis in which molecular mechanisms of epileptogenesis, pharmacological modulation of epileptogenesis, evidence based therapy, refractoriness and prediction of outcome is provided in order to stimulate further collaborative international research.

Keywords: epileptogenesis; evidence; molecular biology; neurobiological mechanisms; rational treatment

Document Type: Research Article


Affiliations: 1: Epilepsy Centre – Neurological Clinic, University Erlangen-Nuernberg, Erlangen, Germany 2: Centre of NeuroSciences, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdan, The Netherlands 3: Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine, Hannover, Germany, and Center for Systems Neuroscience, Hannover, Germany 4: Epilepsy Research Group, Berlin, Germany 5: Institute of Neurology IRCCS C. Mondino Foundation, Pavia, and Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy 6: Epilepsy Unit, University of Glasgow, Scotland 7: Reference Center for Refractory Epilepsy, Department of Neurology, Ghent University Hospital, Belgium 8: Clinical Epilepsy Section, NINDS NIH, Bethesda, MD, USA 9: Departments of Neurology, Neuroscience and Pediatrics and the Comprehensive Epilepsy Management Center, Montefiore Medical Center, Albert Einstein College of Medicine, New York, NY, USA

Publication date: March 1, 2006

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