Skip to main content

Multiple sclerosis trait: the premorbid stage of multiple sclerosis. A hypothesis

Buy Article:

$51.00 plus tax (Refund Policy)

Abstract:

Poser CM. Multiple sclerosis trait: the premorbid stage of multiple sclerosis. A hypothesis.

Acta Neurol Scand 2004: 109: 239–243. © Blackwell Munksgaard 2004.

The unexpectedly low rate of concordance in monozygotic (MZ) twins with multiple sclerosis (MS) suggests that they share a systemic condition called the multiple sclerosis trait. This trait constitutes the premorbid stage of the disease and is quite distinct from asymptomatic MS. It results from the action of an antigenic challenge to the immune system of a genetically susceptible person but is short of producing lesions of the central nervous system parenchyma; in fact, the disease may never develop in people with the trait. An environmental triggering event is required to transform the trait into the disease. The discordance of clinical involvement and magnetic resonance images in MZ twins reflects differences in the effect of environmental influences.

Keywords: environmental triggers; genetic susceptibility; multiple sclerosis; multiple sclerosis trait; twins

Document Type: Review Article

DOI: http://dx.doi.org/10.1111/j.1600-0404.2004.00277.x

Publication date: April 1, 2004

mksg/ane/2004/00000109/00000004/art00001
dcterms_title,dcterms_description,pub_keyword
6
5
20
40
5

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more