Response of thymectomy: clinical and pathological characteristics among seronegative and seropositive myasthenia gravis patients

$48.00 plus tax (Refund Policy)

Download / Buy Article:

Abstract:

Guillermo GR, Téllez-Zenteno JF, Weder-Cisneros N, Mimenza A, Estañol B, Remes-Troche JM, Cantu-Brito C. Response of thymectomy: clinical and pathological characteristics among seronegative and seropositive myasthenia gravis patients.

Acta Neurol Scand 2003 DOI: 10.1046/j.1600-0404.2003.00209.x © Blackwell Munksgaard 2003. Objective –

To identify the response to thymectomy in patients with seronegative and seropositive myasthenia gravis (SPMG). We analyzed the associated diseases, thymus histology, and the severity of symptoms between the two groups. Material and methods – Design –

Descriptive, comparative. Study units –

Fourteen patients with seronegative myasthenia gravis (SNMG) and 57 patients with SPMG who had a thymectomy between 1987 and 1997, with at least 3 years of follow-up. The patients were divided into four groups; (1) Remission, (2) Improvement, (3) No change and (4) Deterioration. Results –

Fourteen patients (20%) were seronegative and 57 were seropositive (80%). In the group of patients with SNMG, three patients were in remission (21%), five with improvement (36%), five with no change (36%) and one with worsening (7%). In the group of patients with SPMG, 12 were in remission (21%), 17 with improvement (30%), 25 with no change (44%) and three (5%) with worsening. The patients with SNMG were older, with less associated diseases and with a lower frequency of thymomas. Conclusions –

The response to thymectomy was similar between the two groups. It has been suggested that seronegative patients have a better prognosis, but our results show no differences.

Keywords: myasthenia gravis; response; seronegative; seropositive; thymectomy; thymoma; thymus histology

Document Type: Research Article

DOI: http://dx.doi.org/10.1034/j.1600-0404.2003.00209.x

Publication date: March 1, 2004

Tools

Favourites

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more