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Apolipoprotein E polymorphism and neuropsychological outcome following subarachnoid haemorrhage

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Morris PG, Lindsay Wilson JT, Dunn LT, Nicoll JAR. Apolipoprotein E polymorphism and neuropsychological outcome following subarachnoid haemorrhage.

Acta Neurol Scand 2003 DOI: 10.1046/j.1600-0404.2003.00206.x © Blackwell Munksgaard 2003. Objectives–

To investigate the association between APOE genotype and cognitive and emotional outcome following spontaneous subarachnoid haemorrhage (SAH). Materials and methods–

Neuropsychological assessments were conducted with 70 SAH survivors derived from a consecutive series of neurosurgical admissions. Outcomes, including cognitive tests, health questionnaires and Glasgow Outcome Scale at a mean of 16 months after SAH, were compared with presence or absence of the 4 allele. Results–

There was no evidence that SAH survivors possessing the 4 allele had poorer outcome. The only suggestion of an association between the 4 allele and outcome was in a subgroup of patients with a Fisher grade 4 haemorrhage, although this trend did not reach statistical significance. Conclusions–

Overall, possession of the APOE 4 allele is not significantly associated with neuropsychological outcome following SAH. However, there may be an effect amongst those with a Fisher grade 4 haemorrhage.
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Keywords: Fisher grade; SAH; Subarachnoid haemorrhage; apolipoprotein E; outcome; stroke

Document Type: Research Article

Affiliations: 1: Department of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh 2: Department of Psychology, University of Stirling, Stirling 3: Department of Neurosurgery, University of Glasgow, Glasgow 4: Division of Clinical Neurosciences, University of Southampton, Southampton, UK

Publication date: 2004-03-01

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