If you are experiencing problems downloading PDF or HTML fulltext, our helpdesk recommend clearing your browser cache and trying again. If you need help in clearing your cache, please click here . Still need help? Email help@ingentaconnect.com

EEG synchronization in mild cognitive impairment and Alzheimer's disease

$48.00 plus tax (Refund Policy)

Download / Buy Article:


Stam CJ, van der Made Y, Pijnenburg YAL, Scheltens Ph. EEG synchronization in mild cognitive impairment and Alzheimer's disease.

Acta Neurol Scand 2003: 108: 90–96. © Blackwell Munksgaard 2003. Objectives –

To compute the synchronization likelihood of multichannel electroencephalogram (EEG) data in Alzheimer (AD) patients, subjects with mild cognitive impairment (MCI) and subjects with subjective memory complaints (SC). Material and methods –

EEGs (200 Hz sample frequency; 21 channels; average reference) were recorded in 10 AD patients (two males; age 76.2; SD 9.36; range 59–86), 17 subjects with MCI (eight males; age 77.41; SD 6.25; range 62–88) and 20 subjects with SCI (11 males; age 68.9; SD 12.96; range: 51–89). The synchronization likelihood, a novel type of coherence measure, was computed, comparing each channel with all other channels, for the 2–6, 6–10, 10–14, 14–18, 18–22 and 22–50 Hz band. Results –

The synchronization likelihood was significantly decreased in the 14–18 and 18–22 Hz band in AD patients compared with both MCI subjects and healthy controls. Lower beta band synchronization correlated with lower Mini-Mental state examination (MMSE) scores. Conclusion –

Loss of beta band synchronization occurs early in mildly affected AD patients and correlates with cognitive impairment.

Keywords: Alzheimer's disease; cognition; coherence; electroencephalogram; mild cognitive impairment; synchronization

Document Type: Research Article

DOI: http://dx.doi.org/10.1034/j.1600-0404.2003.02067.x

Affiliations: 1: Department of Clinical Neurophysiology, 2: Department of Neurology, VU University Medical Centre, Amsterdam, the Netherlands

Publication date: August 1, 2003

Related content



Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more