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Mild cognitive impairment : prevalence and predictive validity according to current approaches

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Busse A, Bischkopf J, Riedel-Heller SG, Angermeyer MC. Mild cognitive impairment: prevalence and predictive validity according to current approaches.

Acta Neurol Scand 2003: 108: 71–81. © Blackwell Munksgaard 2003. Objectives –

Mild cognitive impairment is associated with an increased risk of developing dementia. However, there is no consensus on diagnostic criteria and different concepts have rarely been evaluated in population-based samples. This paper compares the prevalences and predictive validities for different concepts in a population-based study. The aim was to identify a concept with the best relation of sensitivity and specificity in the prediction of dementia. Material and methods –

A community sample of 1045 dementia-free individuals aged 75 years and over was examined by neuropsychological testing in a three-wave longitudinal study. Results –

Prevalence rates ranged from 3 to 36% according to the concept applied. Conversion rates to dementia over 2.6 years ranged from 23 to 47%. In addition, receiver operating characteristic curves indicated that all but one concept for mild cognitive impairment could predict dementia. Conclusion –

Mild cognitive impairment is very frequent in older people. Prevalences and predictive validities are highly dependent on the diagnostic criteria applied.

Keywords: AACD; MCI-amnestic; mild cognitive impairment; outcome; population-based; prevalence

Document Type: Research Article


Affiliations: Leipzig Longitudinal Study of the Aged LEILA75+, Department of Psychiatry, University of Leipzig, Leipzig, Germany

Publication date: 2003-08-01

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