Skip to main content

Effects of rivastigmine on the quantitative EEG in demented Parkinsonian patients

Buy Article:

$51.00 plus tax (Refund Policy)

Fogelson N, Kogan E, Korczyn AD, Giladi N, Shabtai H, Neufeld MY. Effects of rivastigmine on the quantitative EEG in demented Parkinsonian patients.

Acta Neurol Scand 2003: 107: 252–255. © Blackwell Munksgaard 2003. Objectives 

– Quantitative electroencephalogram (qEEG) can be used to measure the effects of drugs on the brain. We studied the effects of rivastigmine on the qEEG in Parkinson's disease (PD) patients with dementia. Subjects and methods 

– Demented PD patients (n=19) were treated with rivastigmine in an open label study. Recordings were obtained prior to and following 12 weeks of treatment. Results were analyzed using two-way ANOVA with repeated measures. Results 

– A significant increase in the relative alpha (P < 0.05) activity was observed after treatment with rivastigmine. This was general rather than localized to specific brain surface areas. An increase in beta activity and decrease in the slower frequencies (delta and theta) were also observed; however, these were not statistically significant. Conclusion 

– qEEG may serve as an objective tool to monitor the effects of antidementia drug therapy. The changes characterized by increased faster frequencies and decreased slower frequencies that were observed may indicate increased arousal or improvement in the cognitive state of the patients as a consequence of the treatment with rivastigmine.
No References
No Citations
No Supplementary Data
No Data/Media
No Metrics

Keywords: Parkinson's disease; cholinesterase inhibitors; dementia; quantitative electroencephalogram; rivastigmine

Document Type: Research Article

Affiliations: 1: Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv; 2: Department of Neurology, Tel-Aviv Sourasky Medical Center, Tel-Aviv;

Publication date: 2003-04-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more