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A case of inflammatory demyelinating polyradiculoneuropathy associated with T-cell lymphoma

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Wada M, Kurita K, Tajima K, Kawanami T, Kato T. A case of inflammatory demyelinating polyradiculoneuropathy associated with T-cell lymphoma.

Acta Neurol Scand 2003: 107: 62–66. © Blackwell Munksgaard 2003.

Malignant lymphoma may present prominent peripheral nervous system disorders with variable etiologies. We describe a patient who presented with chronic relapsing polyradiculoneuropathy accompanied by right facial nerve palsy. Gadolinium enhancement of the right facial nerve and cervical spinal roots was noted on magnetic resonance imaging (MRI). Sural nerve biopsy specimens showed mononuclear cell infiltration around the vessels in the epineurium. Histopathological and immunohistochemical investigations of sural nerve specimens revealed perivascular infiltration of lymphocytes with T-cell dominancy. No apparent direct invasion of lymphoma cells was seen. The results of nerve conduction studies, sural nerve biopsy and cerebrospinal fluid examination were suggestive of immune-mediated inflammatory demyelinating neuropathy. The chronic and relapsing fashion and unique radiological findings in our patient expand on the previously reported features of peripheral neuropathy associated with peripheral T-cell lymphoma.

Keywords: MRI; T-cell lymphoma; cytokine; demyelination; neuropathy

Document Type: Research Article


Affiliations: Third Department of Internal Medicine, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata, Japan

Publication date: January 1, 2003

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