Skip to main content

Superficial siderosis of the central nervous system: pathogenetic heterogeneity and therapeutic approaches

Buy Article:

$48.00 plus tax (Refund Policy)


Leussink VI, Flachenecker P, Brechtelsbauer D, Bendszus M, Sliwka U, Gold R, Becker G. Superficial siderosis of the central nervous system: pathogenetic heterogeneity and therapeutic approaches.

Acta Neurol Scand 2003: 107: 54–61. © Blackwell Munksgaard 2003.

Objective –Superficial siderosis of the central nervous system (CNS) is a rare chronic progressive disorder caused by chronic subarachnoid hemorrhage. We present four patients with superficial siderosis of the CNS to describe the characteristic symptoms, and to discuss the pathogenetic heterogeneity and possible new therapeutic approaches. Results– The causes of chronic subarachnoid bleeding in superficial siderosis were different. In two patients surgical treatment of ependymoma or cerebral cavernomas were the underlying diseases. No cause was detected in one patient. For the first time, we present one patient with vasculitis of the central nervous system associated with systemic hemochromatosis in superficial siderosis. Therapeutic approaches included exstirpation of cavernomas as the source of chronic bleeding in one patient, immunosuppressive therapy and venupunctures in the patient with vasculitis and hemochromatosis, and symptomatic treatment with chelating agents and antioxidants. The patients remained clinically stable for the follow-up period of up to 2 years. Conclusions– Our cases underline the pathogenetic heterogeneity of superficial siderosis and favor the early diagnosis for prompt initiation of therapy. Besides treatment of the underlying condition, antioxidants and radical scavengers may be effective in halting the progression of the disease.

Keywords: hemochromatosis; magnetic resonance imaging; subarachnoid hemorrhage; superficial siderosis; therapy

Document Type: Research Article


Affiliations: 1: Neurology and 2: Neuroradiology, University of Würzburg, Germany; 3: Department of Neurology, University of Hamburg, Hamburg, Germany

Publication date: January 1, 2003


Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more