Skip to main content

Clinical benefits of interferon beta-1a in relapsing–remitting MS: a phase IV study

Buy Article:

$51.00 plus tax (Refund Policy)

Abstract:

Fernández O, Arbizu T, Izquierdo G, Martínez-Yélamos A, Gata JM, Luque G, de Ramón E. Clinical benefits of interferon beta-1a in relapsing–remitting MS: a phase IV study.

Acta Neurol Scand 2003: 107: 7–11. © Blackwell Munksgaard 2003.

Objective– To evaluate the efficacy and safety of IFNβ-1a (Avonex®, Biogen, Inc., Cambridge, MA, USA) in patients with relapsing–remitting multiple sclerosis (MS). Methods– In this multicenter, open-label, prospective clinical trial, 96 patients with relapsing–remitting MS received IFNβ-1a 30 mcg intramuscularly once weekly for 2 years. Outcome variables included: change from baseline in mean number of exacerbations, proportion of exacerbation-free patients, and mean Expanded Disability Status Scale (EDSS) scores at Years 1 and 2. Results– IFNβ-1a significantly (P < 0.0001) reduced exacerbation rate at Years 1 and 2 of treatment. The percentage of exacerbation-free patients was 53% during Year 1 and 33% during Year 2. Mean EDSS scores were 2.96 ± 1.26 at baseline, 2.89 ± 1.42 at Year 1, and 3.00 ± 1.62 at Year 2 (P = 0.116). EDSS scores improved in 35.4%, remained stable in 28.1%, and worsened in 36.5% of patients. IFNβ-1a treatment was well tolerated. Conclusion– This study confirms and extends the beneficial clinical profile for IFNβ-1a in relapsing MS.

Keywords: IFNβ-1a; clinical trial; multiple sclerosis; phase IV study

Document Type: Research Article

DOI: http://dx.doi.org/10.1034/j.1600-0404.2003.01350.x

Affiliations: 1: Department of Neurology, Hospital Regional Universitario Carlos Haya, Málaga, Spain; 2: Department of Neurology, Hospital Universitario de Bellvitge, Barcelona, Spain; 3: Department of Neurology, Hospital Universitario Virgen Macarena, Sevilla, Spain

Publication date: January 1, 2003

mksg/ane/2003/00000107/00000001/art00002
dcterms_title,dcterms_description,pub_keyword
6
5
20
40
5

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more