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Mononeuritis multiplex caused by Coxiella burnetii infection (Q fever)

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Sommer JB, Schoerner C, Heckmann JG, Neundoerfer B, Hilz MJ. Mononeuritis multiplex caused by Coxiella burnetii infection (Q fever).

Acta Neurol Scand 2002: 106: 371–373. © Blackwell Munksgaard 2002.

After 1 week of flu-like illness, a 64-year-old man developed rapidly progressive mononeuritis multiplex involving the right arm and both legs. Serologic studies identified Coxiella burnetii as the cause of the febrile disease (Q fever). Fourteen days doxycycline treatment (200 mg daily) induced rapid and complete recovery. After 6 months, flu-like symptoms, weakness and hypalgesia of the right leg reappeared. Antibody titers again identified Q fever. Doxycycline was re-established and induced prompt recovery. Q fever has been associated with various neurologic complications such as meningoencephalitis, cerebellitis, optic neuritis or polyneuroradiculitis. This is the first report on Q fever related mononeuritis multiplex. Prolonged antibiotic treatment may be required to prevent relapsing infection from the resistant bacterium.
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Keywords: Coxiella burnetii; Q fever; mononeuritis multiplex; peripheral neuropathy

Document Type: Research Article

Affiliations: 1: Department of Neurology, University of Erlangen-Nuremberg, Erlangen, Germany; 2: Department of Clinical Microbiology, Immunology and Hygiene, University of Erlangen-Nuremberg, Erlangen, Germany,

Publication date: 2002-12-01

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