Cerebrospinal fluid levels of insulin in patients with Alzheimer's disease
Abstract:Molina JA, Jiménez-Jiménez FJ, Vargas C, Gómez P, de Bustos F, Gómez-Escalonilla C, Zurdo M, Tallón A, Martínez-Salio A, Porta-Etessam J, Villanueva C, Arenas J. Cerebrospinal fluid levels of insulin in patients with Alzheimer's disease.
Acta Neurol Scand 2002: 106: 347–350. © Blackwell Munksgaard 2002. Objectives –
Some previous reports suggested a potential role of insulin in memory and in the pathophysiology of Alzheimer's disease (AD). We assessed the cerebrospinal fluid (CSF) levels of insulin in patients with AD and in age and sex-matched controls trying to elucidate whether this value could be related with the risk or severity of AD. Patients and methods –
We measured the CSF insulin levels in 27 patients with AD and 16 matched controls using a RadioImmunoanalysis method. Results –
CSF insulin levels did not differ significantly between AD-patient and control groups. These values were not correlated with age, age at onset, duration of the disease, and scores of the MiniMental State Examination in the AD group. Conclusion –
These results suggest that CSF insulin concentrations are not related with the risk or severity of AD.
Document Type: Research Article
Affiliations: 1: Department of Neurology, Hospital Universitario Doce de Octubre, Madrid; 2: Department of Medicine-Neurology, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain; 3: Department of Biochemistry, Hospital Universitario Doce de Octubre, Madrid, Spain
Publication date: December 1, 2002