Surgical treatment of patients with low-grade astrocytomas and medically intractable seizures
Abstract:Objective – Low-grade astrocytomas can present with seizures that respond poorly to antiseizure medications, with a consequent reduction in the quality of life, because of both seizures and the medication's side-effects. We report our experience with operative treatment of such patients. Subjects and methods – Five patients (two children and three adults) with supratentorial low-grade astrocytomas associated with severe seizures were operated on. We followed the effects of the operation on post-operative neurological deficit, seizure frequency and the quality of life. Results – No serious neurological complications followed the operations. The patients were followed for a median period of 12 months (6–46). Post-operatively, three of the patients became seizure-free, one experiences only auras, and one had a great reduction in seizure frequency and severity. All patients reported great improvement in their quality of life. Conclusion – Resections of low-grade astrocytomas in patients with medically intractable seizures are safe procedures that effectively control seizures in the majority of patients, resulting in significant improvement in the patients' quality of life.
Document Type: Original Article
Affiliations: 1: Department of Neurosurgery, The National University Hospital, Reykjavik, Iceland, 2: Department of Neurology, The National University Hospital, Reykjavik, Iceland, 3: Department of Radiology, The National University Hospital, Reykjavik, Iceland
Publication date: April 1, 2002